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Journal of Clinical and Experimental Toxicology | Volume: 03 | ISSN: 2630-4570
allied
academies
November 04-05, 2019 | Prague, Czech Republic
2
nd
World Congress on
TOXICOLOGY AND APPLIED PHARMACOLOGY
Efficacy tests and histological evaluation of a herbal product (VGH) in a rat model
Verónica Edith Gallegos-Hernández
Instituto Politécnico Nacional, Mexico
T
he most common causes of peptic ulcers disease and
its complications are
Helicobacter pylori
infection and
the use of nonsteroidal anti-inflammatory drugs (NSAIDs).
In Mexico there are more than 300 records of medications
that contain the active substance called paracetamol and
68% of the Mexican population that self-medicates, does
so with NSAID´s. As 80% of the population admits having
presented symptoms such as inflammation and abdominal
distension, gastric acidity, bad breath and in some cases
reflux at some point of their lives. We propose the use of
VGH, an herbal product whose obtaining is fast, easy and
economical. The purpose of this study was to perform the
characterization of the VGH product, efficacy tests in mice
and histological evaluations in liver, heart, lung, kidney
and spleen. The characterization of VGH was carried on
through some physiochemical test such as FTIR, optical
absorption, HPLC screening and a phytochemical screening.
The FTIR analysis showed the presence of specific functional
groups: (1) 1000 - 1200 cm
-1
(C-O–C); (2) 1600- 1730 cm
-1
(C=O); (3) 2850 – 2930 cm
-1
(–CH3, -CH2-, =CH-); (4) 338-
3920 cm-1 (OH). The phytochemical screening revealed
the presence of the following groups of molecules:
catechins, sesquiterpenlactones, naphthaquinones and
anthraquinones. VGH increases significantly the platelet
levels in blood, improving the coagulation process. When
administering VGH, the gastric mucosa morphology,
esophagus, mucous membrane of stomach and intestinal
villi showed normal morphology characteristics after VGH
treatment. The administration of the erosive agent caused
the destruction of the gastric mucosa allowing the release of
red blood cells to the lumen of the organs studied, promoting
the migration of leukocytes to the área. The use of GAHV as
a repair agent against previous damage was evident and we
can said that fulfilled the expectations since, despite having
been administered the erosive agent for 14 days at a dose of
0.2 mg / mL / rat / day, the histological analysis showed the
preservation of the normal morphology of the tissue.
Biography
Verónica Edith Gallegos-Hernández is a biotechnological engineer from
the Instituto Politécnico Nacional who has worked in the remediation
of soils contaminated with fossil fuels to improve the wellbeing of her
conational. For her master’s degree, her research is focused on the field
of gastric diseases, specifically in the erosions of the digestive tract
caused by environmental factors.
e:
gavh940112@gmail.comVerónica Edith Gallegos-Hernández, J Clin Exp Tox, Volume: 03
DOI: 10.35841/2630-4570-C2-009