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Journal of Clinical and Experimental Toxicology | Volume: 03 | ISSN: 2630-4570
alliedacademies
November 04-05, 2019 | Prague, Czech Republic
2nd World Congress on
TOXICOLOGY AND APPLIED PHARMACOLOGY
Phytochemical screening and toxicological study of Aristolochia baetica linn roots:
Histopathological and Biochemical evidence
Mohammed Bourhia
Hassan II University, Morocco
A ristolochia baetica (A. baetica) is a wild species of
Aristolochiaceae family, its roots are used by Moroccan
people against cancer for many years ago. The objective of
the study was to investigate the phytochemical screening,
acute and subacute toxicity of A. baetica roots growing
in the north of Morocco. qualitative and quantitative
analysis of A. baetica roots were performed using standard
methods, the acute toxicity of the roots extract of the
studied plant was assessed in mice by gavage of single
doses of 1, 2, and 4 g/kg body weight for 14 days, by the
time the subacute toxicity was done using repeated doses
1, 1.5 and 2 g/kg/day for 28 days. Histological changes,
biochemical parameters as markers of kidney and liver
function were evaluated. The results of phytochemical
screening showed the presence of polyphenols, tannins,
alkaloids, flavonoids, saponins, and the absence of
anthraquinones, sterols, and terpenes. The results of
acute toxicity showed the absence of mortality and signs
of toxicity in groups treated with 1 and 2 g/kg, however,
the clinical signs of toxicity were important and rate of
mortality was estimated at 16 % in the group treated with
4 g/kg. the results of subacute toxicity showed several
changes of serum parameters registered in groups treated
with 1.5 and 2 g/kg/day respectively. The results should
also the absence of histological injuries in groups treated
with 1 and 1.5 g/kg/day, meanwhile, the histological
alterations were remarkable in treated group with the
highest dose administered of 2 g/kg/day. The outcome
of this work showed that the roots extract of the studied
plant was toxic in mice with repeated doses, but no toxic
effect was observed with a single dose under 4g/kg.
e:
J Clin Exp Tox, Volume: 03
DOI: 10.35841/2630-4570-C2-009
Notes: