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Journal of Clinical and Experimental Toxicology | Volume: 03 | ISSN: 2630-4570
alliedacademies
November 04-05, 2019 | Prague, Czech Republic
2nd World Congress on
TOXICOLOGY AND APPLIED PHARMACOLOGY
The effect of hard drinking water with elevated concentrations of Calcium or
Magnesium on Renal functions and metabolism in rats
Aizman Roman Idelevich
Novosibirsk State Pedagogical University, Russia
There are conflicting data in the literature on the impact
of hard drinking water, due to the high content of
magnesiumorcalciumsalts
connection with the above, the aim of this work was to study
the effects of prolonged consumption of drinking water with
high content of ions Ca2+ or Mg2+ on hydro- and ionuretic
renal functions and biochemical parameters of blood plasma
in Wistar rats. 3 groups of animals were studied: control
animals on standard feed and water consumption (Ca2+ =
20 mg/dm3; Mg2+= 6 mg/dm3); and 2 experimental groups,
consumingfor5weekswaterwithanincreasedconcentration
of Ca2+ (120mg/dm3) or Mg2+ (70mg/dm3). Renal function
was studied by collecting background urine samples within 4
hours and 3 hours after oral 5% of body weight water load.
At the end of the experiment, blood was collected to assess
the homeostatic parameters of plasma. The concentrations
of electrolytes and osmotically active substances in urine
and plasma were determined using the methods of flame
photometry and cryoscopy. Calculation of water and ionic
renal functions was carried out according to the generally
accepted formulas. Set of indicators characterizing the rat's
response to long-term drinking water intake with a high
content of Ca2+ or Mg2+, leads to the conclusion that after 5
weeks of such water consumption there was an activation of
osmo-regulatory mechanisms in both experimental groups.
The difference between the ion-regulating indicators in
experimental groups compare to control was expressed to a
greater degree following the consumption of drinking water
with a high magnesium content. Water loadings reduced the
stress of osmo- and ion-regulating mechanisms, probably
due to increase of dilution process. These results indicate
the influence of surplus cations intake on osmo- and ion-
regulating mechanisms of water-mineral balance.
Biography
Aizman Roman Idelevich, is a Doctor of Biological Sciences, Professor,
Honored Worker of Science of Russia, Head of the Department of
Anatomy, Physiology and Safety, Director of the Institute of Health
and Safety. He is a member of 3 dissertation councils for doctoral
theses, a foreign member of the American Physiological Society, a valid
Member of the European Society of Pediatric Nephrology, associate
editor of two scientific journals. Under his leadership 8 doctoral and 40
candidate's theses on problems of developmental and renal physiology,
physiological-hygienic effects of drinking water were defended. He
is a author of over 500 scientific and methodical works, including 28
monographs, 90 manuals, 367 articles in refereed journals and 16
proposals, patents, registration certificates. He is awarded diplomas
of the Ministry of Education of the Russian Federation, Ministry
of Emergency Situations, the Administration of the city and region
(Novosibirsk) the Medal "Property of Siberia", K.D. Ushinsky medal.
e:
Aizman Roman Idelevich, J Clin Exp Tox, Volume: 03
DOI: 10.35841/2630-4570-C2-009