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Journal of Biomedical Research | ISSN: 0976-1683 | Volume 30
March 14-15, 2019 | London, UK
T issue Engineer ing, Stem Cel ls and Regenerat ive Medicine
Cel l and Gene Therapy
World Congress on
International Conference on
&
Joint Event
Regeneration of liver by
Platycladus orientalis
extract
Alok Kumar Dash
V B S Purvanchal University, India
L
iver is a vital organ of our body performing wide range of
functions. Regeneration of liver by through plant extract is
safe and having better patient compliance. Present study was
aimed at evaluating protective ability of
Platycladus orientalis
Linn
against paracetamol induced hepatotoxicity in rats.
When these extracts screened for hepatoprotective activity,
the results obtained from paracetamol induced hepatotoxic
model in the healthy male Wister rats indicates that, after the
treatment with paracetamol there was significant rise in SGOT,
SGPT, ALP and total bilirubin levels which were lowered by
petroleum ether extract of
Platycladus orientalis
leaf, sylimarin
25 mg/kg was taken as the standard drug. In the whole process
of hepatotoxicity thioacetamide was used for toxified the liver
and it showed same result as like paracetamol in toxification.
In order to detect the oxidative stress in lipid peroxidation in
liver checked it’s
in-vivo
antioxidant parameter like reduced
glutathione (GSH), thiobarbituric acid reactive substances
(TBARS), catalase (CAT) and superoxide dismutase (SOD) which
justify the antioxidant property of both the plant. Which also
justify the hepatoprotective and antioxidant effect of the
plant. The biochemical observations were supplemented by
histopathological examination of pancreas and liver section.
In histopathological observation, it was showed that the
petroleum ether extract of Platycladus orientalis possess
effectively hepatoprotective property.
Speaker Biography
Alok Kumar Dash has completed B. Pharm from IGIP, M. Pharma from KMIPS and Ph.D.
degree from Suresh Gyan Vihar University (SGVU) in Rajasthan, India. He is working as an
assistant professor in Institute of Pharmacy, Veer Bahadur Singh Purvanchal University
in Uttar Pradesh, India. His field of research focuses on natural products chemistry,
pharmacognosy, pharmacological screening and standardization method development
for herbals. He has more than 40 national and nternational publications and 2 patents in
his credit. His biography is published Asian Admirable Achievers in 2016. He received the
globally reputed ‘Rashtriya Gaurav Award’-2017. His profile is selected for Bharat Vikas
Award Recipient of “Certificate of Excellence in Reviewing-2017” by European journal of
medicinal plant, Science Domain International and has been serving as an editorial board
member of International Journal of Modern botany Scientific &Academic Publishing, Asian
Journal of Chemical Sciences and many more.
e:
alokkudash@yahoo.co.inAlok Kumar Dash
, Biomed Res, Volume 30
DOI: 10.4066/biomedicalresearch-C1-025