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Journal of Biomedical Research | ISSN: 0976-1683 | Volume 30
allied
academies
March 14-15, 2019 | London, UK
T issue Engineer ing, Stem Cel ls and Regenerat ive Medicine
Cel l and Gene Therapy
World Congress on
International Conference on
&
Joint Event
A
dult stem cells are a promising cell source for tissue
regeneration. Due to the limited size of biopsy which
provides small amount of stem cells,
ex vivo
expansion is
necessary for acquiring a large quantity of stem cells with
differentiation capacity. Unfortunately,
in vitro
expansion
in 2D renders the cells senescent. Recently, decellularized
extracellular matrix provides a 3D matrix microenvironment
to efficiently expand tissue-specific stem cells for tissue
engineering and regeneration. This matrixmicroenvironment
can not only promote stem cell proliferation capacity but also
determine lineage preference of adult stem cells. Despite the
necessity for further in-depth investigation, this 3D matrix
might bring the potential for future tissue engineering and
regeneration.
Speaker Biography
Ming Pei completed his PhD from Beijing University, China and postdoc training from
Harvard-MIT Division of Health Sciences and Technology, USA. Currently, he is a tenured
professor and director of stem cell and tissue engineering laboratory in the Department of
Orthopaedics, West Virginia University, USA. He has over 100 publications that have been
cited over 3100 times and his publication h-index is 32 and has been serving as an editorial
board member of reputed Journals.
e:
mpei@hsc.wvu.eduMing Pei
West Virginia University, USA
Matrix microenvironment mediated fate determination of stem cells
Ming Pei
, Biomed Res, Volume 30
DOI: 10.4066/biomedicalresearch-C1-024