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Biomedical Research
|
Volume 29
Page 35
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Joint Event on
STUDY ON THE DOSE EVALUATION
VARIATION OF LEFT VENTRICULAR
MYOCARDIAL AND LEFT ANTERIOR
DESCENDING INDUCED BY HEARTBEAT
IN LEFT BREAST CARCINOMA
RADIOTHERAPY
Qian Li
Shandong University, China
Purpose:
To study the dose evaluation variation of left ventricular
myocardial (mLV) and left anterior descending (LAD) induced by heartbeat
in intensity modulated radiotherapy (IMRT) of left breast carcinoma.
Methods:
15 female patients were enrolled. All the patients received
electrocardiography gated 4D-CT scan in inspiration breath hold, and
CT images were sorted into 20 phases (0%, 5%……90%, 95%) according
to cardiac cycle.Then, the mLV and LAD were delineated slice by slice,
and the left breast carcinoma IMRT plans were designed on 0% phase
CT images.The volume and dice similarity coefficient (DSC) of mLV were
calculated, and the V10, V20, V30, V40 and Dmean of LAD and mLV were
compared among different phases.
Results:
(1) The average rate of DSC variation of mLV was eightfold
of volume, which reached to 472.07% with statistically significant
difference (P<0.001).(2)The average rate of variation of mLV Dmean
was (18.74±9.32)%, up to 41.95%，and the difference was statistically
significant (P<0.001); the variation range of V10, V20, V30 and V40 of
mLVwere (10.06±9.21)%, (9.24±9.63)%, (8.45±9.66)% and (6.86±10.00)%,
and the difference was statistically significant (P<0.05).(3)The average
rate of variation of LAD Dmean was (58.88±29.10)%, up to 130.14%, and
the difference was statistically significant (P=0.001); the variation range
of V10, V20, V30 and V40 of LAD were (28.52±12.11)%, (29.35±12.65)%,
(28.84±13.74)% and (26.35±15.89)%, and the difference was statistically
significant (P<0.001).
Conclusion:
The dose evaluation variation of mLV and LAD which were
induced by heartbeat should not be ignored. Our study provided a
reference for the accurate prediction of cardiac toxicity, and that could
benefit to protection of heart and cardiac sub-strcture.
lq18711443361@163.comQian Li, Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-005