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Biomedical Research
|
Volume 29
Page 26
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Joint Event on
RADIOFREQUENCY CATHETER
ABLATION OF FREQUENT PREMATURE
VENTRICULAR COMPLEXES
INFLUENCES LEFT VENTRICULAR
FUNCTION
Agnieszka Wojdyla-Hordynska
University Hospital Opole, Poland
F
requent premature ventricular complexes (PVC) are related to
reversible tachycardia-induced cardiomyopathy. However, the role
of arrhythmia burden on the outcome of the catheter ablation has not
been fully recognized. The aim of this study was to assess the effect of
catheter ablation and PVC burden in patients with and without structural
heart disease (SHD) on left ventricular ejection fraction (LVEF).
Methods:
Transthoracic echocardiography was done before and six
months after radiofrequency catheter ablation in 109 consecutive
patients (61 men, age 55 ± 17 years) with frequent PVCs. Sixty-five
(59.6%) patients had underlying SHD.
Results:
The catheter ablation procedure was successful in 93 (85.3%)
patients. Baseline PVC burden was higher in patients with SHD (22,267
± 12,934) compared to those without concomitant SHD (15,546 ± 7888),
p = 0.005. Nevertheless, patients with LVEF ≤ 50% at baseline presented
greater LVEF recovery (from 44% to 56%) than those with LVEF > 50% at
baseline after catheter ablation. In both groups, the LVEF improved (p <
0.001); however, no difference was observed between patients with SHD
(5.7% ± 1.37%) and without (4.6% ± 0.96%) SHD; p = 0.89. PVC burden
was higher in patients with (24,350 ± 2776 PVC/day) compared to those
without (17,588 ± 1970 PVC/day) improvement of LVEF. In multivariate
regression analysis PVC burden > 20,000/day (but not age, p = 0.95;
gender, p = 0.89; presence of SHD, p = 0.53; QRS complex width of the
treated PVC, p = 0.21, LVEF before ablation, p = 0.19; and site of origin, p
= 47) predicted improve¬ment in LVEF after successful catheter ablation
(odds ratio: 3.53; 95% confidence interval: 1.15–10.75; p = 0.023).
Conclusions:
Catheter ablation of frequent PVCs improves left ventricular
function and in multivariate analysis predicted improvement of LVEF
within six months after the successful catheter ablation procedure in
patients with PVC burden exceeding 20,000/24 h.
Agnieszka Wojdyła-Hordynska has completed
her Medical Doctor from Silesian University (Po-
land), she has reached an MBA degree in Health
Care Management in 2012 in University Opole,
Poland, successfully finished her cardiology
and interventional electrophysiology training in
2013, started her PhD studies in Silesian Uni-
versity in 2017. She is an assistant doctor in
the Clinical Cardiology Department and Elec-
trophysiology Laboratory of University Hospital
Opole in Poland. In the years 2010-2011 she has
been awarded by EHRA, a clinical electrophysi-
ology fellowship in HZL, Leipzig, Germany. She
proceeds her research in ventricular arrhyth-
mias and means of ablation, as well as devices
and heart failure management. She is a skilled
operator, interventional electrophysiologist and
device implanting doctor.
agniwoj@o2.plBIOGRAPHY
Agnieszka Wojdyla-Hordynska, Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-005