7 / 11
Page 34
allied
academies
November 21-22, 2019 | Singapore
Global Experts Meeting on
12
th
International Conference on
STD-AIDS and
Infectious Diseases
Allergy, Immunology
and Rheumatology
Joint Event
&
J Infectious Disease Med Microbiol, Volume 3
Skin dendritic cells: The sentinel paradox
Baptiste Janela
Skin Research Institute of Singapore (SRIS) , Singapore
Singapore Immunology Network (SIgN), Singapore
A
s the largest barrier organ in the body, the skin is a
challenging immune site, requiring vigilance for invading
pathogens, coupled with tolerance to self, environmental
antigens, and the microbiota. Dendritic cells (DC) are
professional pathogen-sensing and antigen-presenting cells
(APC)thatarecentraltotheinitiationandregulationofimmune
responses. In the skin, three subsets of ontogenetically-
distinct and functionally-specialized conventional DC (cDC)
exist: cDC1, cDC2 and Langerhans cells. Together, these APC
populations sense and integrate multiple signals from the
internal and external environments in order to initiate and
shape optimal immune responses. Thus DC biology is at the
center of allergic and autoimmune skin conditions, as well
as pathogen infections, wound healing and skin cancers and
promising targets for next-generation immunotherapies.
However, understanding the roles of the DC populations
and their interactions with other immune cells in the skin
is necessary for the development of improved therapies for
such conditions. In this symposium, I will introduce a new
and essential role for cDC1 in the regulation of neutrophil
biology and highlight a new role of the minor cDC1 subset
in the regulation of mouse and human skin innate immunity
that goes beyond antigen presentation and T cells priming.
e
:
Baptiste_Janela@immunol.a-star.edu.sgJournal of Infectious Diseases and Medical Microbiology | Volume 3
Notes: