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academies
November 21-22, 2019 | Singapore
Global Experts Meeting on
12
th
International Conference on
STD-AIDS and
Infectious Diseases
Allergy, Immunology
and Rheumatology
Joint Event
&
J Infectious Disease Med Microbiol, Volume 3
Application of two novel NGS-based detection methods in HPV genomic studies
Zhu Houshun
Beijing Genomics Institute (BGI), China
H
uman papillomavirus (HPV) is deemed as the leading
causeof cervical cancerwhich is the fourthmost common
cancer in women. Here we will show two novel detection
assays applied in genomic studies of HPV based on NGS.
Probe seq could be used in the scenario of acquiring the full
virus genome and integration sites at the same time fromHPV
positive swabswhichare collected inHPV routine surveillance.
Single tube long fragment read (stLFR) technology could
be performed on large molecular HPV genomes which are
amplified through rolling cycle amplification (RCA). stLFR shed
light on revealing differences among HPV viruses in the same
host and may help in illuminating important virus mutations
that contribute to the progress after virus infection. The two
novel HPV detection methods are developed and tested and
showed potential in HPV genomic studies, as well as in finding
new targets for HPV infection prognosis.
Speaker Biography
Zhu Houshun has completed his PhD study in 2017 at The University of
Hong Kong. He became the researcher of BGI, China from the year 2018
and employed as a visiting professor by Anhui Medical University at 2019.
He has 14 publications that have been cited over 200 times. Themain study
filed of Houshun is focused on pathogenesis of infectious pathogens such
as influenza virus as well as HPVs
e:
houshunzhu@gmail.comJournal of Infectious Diseases and Medical Microbiology | Volume 3