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allied
academies
November 21-22, 2019 | Singapore
Global Experts Meeting on
12
th
International Conference on
STD-AIDS and
Infectious Diseases
Allergy, Immunology
and Rheumatology
Joint Event
&
J Infectious Disease Med Microbiol, Volume 3
Neoantigen discovery in non-small cell lung cancer
Asma Khanniche
Shenzhen Institutes of Advances Technology, China
Advances in next generation sequencing and bioinformatics
have allowed the prediction and the identification of
neoantigens that are endowed with exquisite tumor
specificity and ability to induce T cell reactivity, which
render them promising targets for cancer immunotherapies.
Herein, taking into consideration the prevalence of the
HLA-A0201 allele, we aimed at identifying a set of HLA-A0201
restricted neoantigens in NSCLC patients and evaluating their
immunogenicity and specificity. Results showed the presence
of immunogenic neoantigens; derived form genes such as
TP53 and CDH10, etc. that are experimentally good binders
with high affinity and ability of inducing a T cell response
in vitro as compared to their WT counterparts suggesting
a higher immunogenicity and specificity. These findings
warrant more investigation of the therapeutic applications of
these neoantigens aiming at enhancing anti-tumor immunity.
e
:
asmakhanniche@hotmail.comJournal of Infectious Diseases and Medical Microbiology | Volume 3
Notes: