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Journal of Dermatology Research and Skin Care | Volume 2
May 14-15, 2018 | Montreal, Canada
Spring Dermatology &
Skin Care Expo Conference
G
ardner Diamond Syndrome (GDS), also referred to as
auto-erythrocyte sensitization syndrome or psychogenic
purpura, is a rare psych dermatological condition
characterized by the formation of spontaneous, painful skin
lesions that develop into ecchymosis following episodes of
severe physiological or psychological stress. The majority of
GDS cases occur in young adult females and although the
etiology of this rare disorder is unknown, there appears to be
a psychological component correlated with the co-existence
of previous psychiatric diagnoses. Due to the rare nature of
this disorder, there exist few guidelines for prompt clinical
diagnosis and optimal treatment. Here, a systematic review
was conducted to include 45 international cases of patients
with GDS to better understand clinical presentation as well as
current treatment options. Ultimately, GDS is a diagnosis of
exclusion after other coagulopathies and causes of purpura
are ruled out. High clinical suspicion following laboratory
and clinical exclusion of known physiological causes is
necessary for diagnosis. Selective serotonin reuptake
inhibitors (SSRIs) and corticosteroids are cost effective first
line treatments for GDS with proven efficacy in symptomatic
relief. GDS refractory to initial treatment may require regular
psychotherapy and titrated SSRI dosages to achieve long-
term success. This review of available case studies serves
to comprehensively describe the clinical presentation and
available treatment approaches to this rare disorder.
e:
MeganBlock@creighton.eduGardner diamond syndrome: A systematic review of treatment options
Megan Block
Creighton University School of Medicine, USA