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Journal of Dermatology Research and Skin Care | Volume 2
May 14-15, 2018 | Montreal, Canada
Spring Dermatology &
Skin Care Expo Conference
T
he continuous exposure of skin to ultraviolet radiations
generates reactive oxygen species leading to photoaging
that causes degradation of dermal collagen and degeneration
of elastic fibers. These fibres provide mechanical strength to
the skin. In order to maintain the appearance of the skin,
a complete understanding of the mechanism behind skin
cellular degradation is desired, so that a better cosmetic
formulation can be formulated. The studies has been shown
that macrophages are crucially involved in skin Carcinoma
and express significantly higher levels of M1 (CD40, CD127)
and M2 (arginase I) markers as well as higher levels of
MMP-9, a pivotal enzyme in cancerous matrix remodeling
and cancerous invasion, than macrophages from the basal
cell carcinomas. These macrophages represents different
receptors like folic acid receptors which was exploited to
know the extent of efficacy for delivery of phyto-formulations
containing nanoparticles, transferosomes, liposomes etc. to
cure carcinoma. The flavanoidal rich natural bioactives have
been extensively incorporated in a suitable base and have
proven their potential as a topical photoprotectants but their
activity remained restricted due to poor solubility profile.
Now researchers are working to design the Novel Targeted
formulations to deliver these natural flavanoidal drugs to
improve its efficacy and ultimately skin properties. In current
years, The focus area of work is on some traditionally used
bioactive moieties as natural matrix metalloproteinases
inhibitors (MMPIs) and emphasized on more extensive and
specific studies, so that a good combination of natural as
well as synthetic MMPIs with the conventional drugs can be
used for treating UV radiations induced ailments.
e:
swarnlata_saraf@rediffmail.comPhyto-formulations for matrix metalloproteinases (MMPs): Novel targets in UV radiation induced skin
carcinoma
Swarnlata Saraf
Pt Ravishankar Shukla University, India