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Journal of Dermatology Research and Skin Care | Volume 2
May 14-15, 2018 | Montreal, Canada
Spring Dermatology &
Skin Care Expo Conference
Introduction: Although many options are available to
eliminate condiloma acuminate lesions, none of them
prevents relapses. Patients and method: A prospective,
open, controlled study was carried out to compare the
therapeutic effectiveness of cryosurgery plus interferon
alfa-2b (IFN) versus cryosurgery alone in the treatment of
condiloma acuminata. We included 170 adult patients with
this diagnosis. There were two groups of 85 patients each.
Patients from group I received IFN 3×106 IU three times a
week plus fortnightly application of cryosurgery. Patients
in group II received fortnightly application of cryosurgery
alone. Treatment duration was the same (six weeks) in each
group. Therapeutic effectiveness was assessed two weeks
after treatment completion by comparing the initial and nal
state of the lesions. Patients showing complete treatment
response were followed up quarterly for five years to detect
possible relapses. Relapse was the main outcome variable of
this study. Adverse events were monitored throughout the
study.
Results:
Relapse rates were signi cantly lower in group I. The
start-end comparative analysis showed a signi cantly better
response to the treatment in group I. The most common
adverse effects were: fever, headache, chills, and myalgias
due to IFN and burning due to cryosurgery. None of these
events was serious.
Conclusions:
Cryosurgery plus IFN is more effective than
cryosurgery alone. The combined treatments decreased the
relapse rate from 100% to 5.1%. Adverse effects were mild or
moderate and not serious.
e:
isralfonso@infomed.sld.cuCryosurgery plus interferon alfa-2b versus cryosurgery alone in the treatment of condyloma acuminata
Israel Alfonso Trujillo
Hospital Hermanos Ameijeiras, Cuba