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Page 68
allied
academies
Journal of Dermatology Research and Skin Care | Volume 2
May 14-15, 2018 | Montreal, Canada
Spring Dermatology &
Skin Care Expo Conference
Background:
Vitiligo is a common pigmentary disorder with
great cosmetic and psychological morbidities. Althoughmany
treatment modalities have been tried for the treatment of
vitiligo, none is uniformly effective. PUVA (Psoralen Ultra
Violet A) is established as efficacious treatment for vitiligo.
Recently, narrow band UVB(NBUVB) has been reported
to be an effective and safe therapeutic option in patients
with vitiligo. In this study, patients with vitiligo divided into
two groups that were treated either with UVB or PUVA
therapy modalities and the efficacy ,the time required for
repigmentation, stability of repigmentation and adverse
effects were compered in two groups.
Methods:
A clinical trial has been performed on 60 patients
with vitiligo referred to BOUALI hospital and MEHREGAN
laser center in 1392 and treated with UVB and PUVA
therapy methods. In first group that were treated with PUVA
(30 patients), oral tablets containing 8-methoxypsoralen
at a dose of 25 mg/m
2
were taken three hours before
phototherapy and PUVA therapy was started at a dose of 0.5
J/cm
2
twice a week. The phototherapy dose was increased by
20% in each visit if tolerated. In second group( 30 patients),
UVB therapy was administered twice a week with 311-313
nm wavelength and a dose of 0.1 J/cm
2
and we increased the
dose 20% in each visit if tolerated. Phototherapy sessions in
both groups were 15. In patients treated with PUVA, 40%
were male (12 patients) and 60% were female (18 patients).
In UVB group 43.3% were male (13 patients) and 56.7%
were female (17 patients). The mean age in PUVA- treated
group is 34 years and in UVB treated group is 32.1 years.
There was no statistically significant difference on comparing
mean age in both groups.(p=0.13). Type of vitiligo in patients
treated with PUVA was 56.7% generalized, 30% segmental
and 13.3% focal, and in patients treated with UVB was 56.7%
generalized, 33.3% segmental and 10% focal.
Result:
In the PUVA- treated group three month after
treatment, two patients showed complete repigmentation
(6.7%), five patients showed excellent repigmentation
(16.7%), 17 patients showed good repigmentation (56.7%),
four patients showed moderate repigmentation (13.3%),
one patient showed mild repigmentation (3.3%) and one
patient showed no improvement (3.3%). In the UVB–
treated group three month after treatment, six patients
showed complete repigmentation (20%), 13 patients
showed excellent repigmentation(43.3%), eight patients
showed good repigmentation (26.7%), two patients showed
moderate repigmentation (6.7%). One patient showed mild
repigmentation (3.3%). In this study ,there was statistically
significant relationship between repigmentation and type of
treatment during three and six month so that the efficacy in
patients treated with UVB is better than PUVA.
Conclusion:
According to this study, using UVB phototherapy
is a safe and effective way for treatment of vitiligo in
comparison with PUVA phototherapy.
e:
marjanentezami@yahoo.comComparison of the Therapeutic Effects of UVB and PUVA Therapy in Patients with Vitiligo Referred to BOUALI
Hospital and MEHREGAN Laser Center
Marjan Entezami
Islamic Azad University, Iran