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July 05-06, 2019 | Paris, France
Pharmaceutics and Advanced Drug Delivery Systems
2
nd
International Conference and Exhibition on
Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN:2249-622X | Volume 9
Correlation between Serum Vitamin D concentration status and Matrix
Metalloproteinase-9 in patients undergoing Elective Percutaneous Coronary
Intervention
Mahtabalsadat Mirjalili, Ehsan Mirzaei
and
Farzaneh Foroughinia
Shiraz University of Medical Sciences,Iran
Backgrounds:
Cardiovascular diseases (CVD) including
atherosclerosis and coronary artery diseases (CAD) have
become increasingly threatening to people’s lives during
recent decades. Several studies have shown that matrix
metalloproteinase-9 (MMP-9) plays an important role
in the process of atherosclerosis and heart remodeling
and it has been suggested that higher MMP-9 levels are
associated with higher risk of CVD. On the other hand,
Vitamin -D deficiency have been recognized as a risk
factor for CAD. According to the prevalence of vitamin D
deficiency in our country, Iran, we aimed to evaluate the
relationship between vitamin D status and the level of
MMP-9 in patients undergoing percutaneous coronary
intervention (PCI).
Methods:
In this prospective cross-sectional study, patients
who were candidates for elective coronary intervention
were included. Baseline serum MMP-9 and vitamin D levels
were measured. Patients were categorized into three groups
according to their vitamin D serum level: Vitamin D-severely
deficient (≤ 10 ng/ml), vitamin D-moderately deficient (11-20
ng/ml), and vitamin D-insufficient/sufficient (> 21 ng/ml).
Results:
Totally, 150 patients were assessed for the serum
level of MMP-9 and vitamin-D. The analysis showed that
serum MMP-9 levels were higher in patients with lower
vitamin-D concentrations. A significant inverse correlation
was found between MMP-9 concentration and 25(OH)
vitamin D level (P = 0.039).
Discussion:
It may be concluded that low vitamin D level may
lead to more vulnerable plaques and consequently more
cardiovascular adverse effect in post-PCI patients.
Speaker Biography
Mahtabalsadat Mirjalili is currently working as a Junior Clinical Pharmacy
Resident in Shiraz University of Medical Sciences, Iran. She has completed
Doctor of Pharmacy from Shahid Sadoughi University of Medical Sciences,
Iran. Her researchworks focus on antibiotic therapy and intensive care unit.
She has published her research works in several National and International
Conferences as well as in several reputed Journals.
e:
mahtab.mirjalili@gmail.comMahtabalsadat Mirjalili et al.
, Asian J Biomed Pharmaceut Sci, | ISSN: 2249-622X
Volume 9