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July 05-06, 2019 | Paris, France
Pharmaceutics and Advanced Drug Delivery Systems
2nd International Conference and Exhibition on
Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN:2249-622X | Volume 9
Hepatoprotective effect of Achyranthes Aspera extract on non-alcoholic fatty liver
in mice
Tae Woo Oh, Hyun Ju Do, Kwang Il Park
Korea Institute of Oriental Medicine, South Korea
Non-alcoholic fatty liver disease is a common disease with
accumulationof liver fat, and it occurswithout thehistory
of alcohol consumption, which has the same characteristics
as alcoholic fatty liver and histologic findings. The aim of
this study was to determine whether administration of
Achyranthes aspera extracts (AAE) prevents diet induced
nonalcoholic fatty liver disease. Male C57BL/6 mice (7 weeks
old; initial weight 22.3 g) were randomly assigned into two
groups after a 1-week adaptation period: normal control diet
(CTL group) and high fat diet (HF group). CTL group and HF
group freely received normal control diet and high fat diet
respectively. After 12 weeks adaptation period, the HF group
were assigned randomly to two groups and further fed an
HFD (HF group) or an HFD supplemented with AAE (A500
group). After 4 weeks, we evaluated the body weight, serum
metabolic parameters, and expression of mRNAs related to
hepatic fatty acid uptake and de novo lipogenesis. The HF
group exhibited higher weight gain throughout the body
and liver than the CTL and A500 groups did. The HF group
also showed greater expression of LXRα, LXRβ, SREBP1c,
SREBP2, and C/EBPα mRNAs in the liver than the CTL and/or
A500 groups. In addition, expression of ACC1, FAS, and SCD-1
mRNA in the liver were reduced, while expression of PPARγ
mRNA was lower in the A500 group than in the HF group.
Hepatic expression of p-AMPK/AMPK was higher in the
A500 group than in the HF group. Accordingly, AAE prevents
anti-inflammatory, anti-obesity and ameliorative liver fatty
degeneration effects. This study provides novel information
concerning the protective effect of AAE supplementation
against obesity-induced nonalcoholic fatty liver disease.
e
Asian J Biomed Pharmaceut Sci, | ISSN: 2249-622X
Volume 9