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O c t o b e r 1 9 - 2 0 , 2 0 1 8 | T o k y o , J a p a n
Pharma Congress 2018 & Molecular Medicine 2018
& Psychiatric Disorders 2018
Asian Journal of Biomedical and Pharmaceutical Sciences
|
ISSN: 2249-622X
|
Volume 8
International Conference on
PHARMACEUTICS AND NOVEL DRUG DELIVERY SYSTEMS
19
th
International Conference on
CELLULAR AND MOLECULAR MEDICINE
19
th
Annual Congress on
PSYCHIATRY AND PSYCHIATRIC DISORDERS
&
&
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
alliedacademies.comYEARS
Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C3-009
STRUCTURE-BASED DESIGN FOR BINDING PEPTIDES IN ANTI-CANCER
THERAPY
John Yu
Chang Gung University, Taiwan
T
he conventional anticancer therapeutics usually lack cancer specificity, leading to damage of normal tissues that patients
find hard to tolerate. Ideally, anticancer therapeutics carrying payloads of drugs equipped with cancer targeting peptides can
act like “guided missiles” with the capacity of targeted delivery toward many types of cancers. Peptides are amenable for con-
jugation to nano drugs for functionalization, thereby improving drug delivery and cellular uptake in cancer-targeting therapies.
Peptide drugs are often more difficult to design through molecular docking and
in silico
analysis than small molecules, because
peptide structures are more flexible, possess intricate molecular conformations, and undergo complex interactions. In this
report, the development and application of strategies for structure-based design of cancer-targeting peptides against GRP78
are discussed. The author will also cover topics related to peptide pharmacokinetics and targeting delivery, including molecular
docking studies, features that provide advantages for
in vivo
use, and properties that influence the cancer-targeting ability. Some
advanced technologies and special peptides that can overcome the pharmacokinetic challenges have also been included.