7 / 18
Page 38
O c t o b e r 1 9 - 2 0 , 2 0 1 8 | T o k y o , J a p a n
Pharma Congress 2018 & Molecular Medicine 2018
& Psychiatric Disorders 2018
Asian Journal of Biomedical and Pharmaceutical Sciences
|
ISSN: 2249-622X
|
Volume 8
International Conference on
PHARMACEUTICS AND NOVEL DRUG DELIVERY SYSTEMS
19
th
International Conference on
CELLULAR AND MOLECULAR MEDICINE
19
th
Annual Congress on
PSYCHIATRY AND PSYCHIATRIC DISORDERS
&
&
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
alliedacademies.comYEARS
Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C3-009
FLUORESCENT AND T1 MRI ACTIVE MULTILAYER NANOPARTICLE FOR
IMAGING AND TARGETING CELLULAR DELIVERY
Oara Neumann
Rice University, USA
M
ultifunctional plasmonic nanostructures have enormous potential in the treatment of solid tumors; however, tracking parti-
cles with drug cargo and triggering the release of the cargo in mapped tumors is still impossible. To overcome this challenge
we have developed an MRI and fluorescent active nanostructure nanomatryoshka. This new nanostructure with IR plasmonic
signatures is composed of a 50 nm Au core surrounded by dye molecules and Gd(III)-DOTA chelate doped SiO2 inner-shell and
an outer Au shell. The experimental results demonstrates an enhanced T1 relaxation (r
1
~24 mM
-1
s
-1
at 4.7 T) compared to the
clinical Gd(III)-DOTA chelating agents (r
1
~4 mM
-1
s
-1
). Further, this design preserves the fluorescence signal (65%) after 24 hours
of exposure, leading to enahanced fluorescence photostability (23x). This dual-imaging functionality nanosystem increases MRI
sensitivity by concentrating Gd(III) ions into the Gd-NMs, reduces the potential toxicity of Gd(III) ions and dye molecules by pre-
venting their release
in vivo
through the outer Au shell protection, and the terminal gold layer surface can then be functionalized to
increase cellular uptake, circulation time, or thermal drug-release properties.