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September 20-22, 2017 | Toronto, Canada
10
TH
AMERICAN PEDIATRICS HEALTHCARE &
PEDIATRIC INFECTIOUS DISEASES CONGRESS
Pediatric Healthcare & Pediatric Infections 2017
Objective:
To study risk factors for Enterobecter sepsis and sensitivity
pattern of the organism.
Method:
Prospective hospital based study, conducted at tertiary neonatal
intensive care unit of Ziauddin University Hospital from January 2011 to
December 2014. Blood specimens for culture from 2166 babies were sent.
Repeat cultures done when the neonate did not show improvement or
deteriorated on first line antibiotics. Risk factors were looked for. Antibiotic
resistance of the isolate was studied by the disk diffusion technique.
Results:
There were 540 (24.93%) cases of culture proven sepsis.
Enterobecter was grown in 84 (15.55%) cases. Among the gram negative
organism Enterobecter was the commonest organism n= 84(15.5%)
followed by pseudomonas n= 54 (10%). Among the gram positive organism,
Staph Lugdunensis seen in 150 (27.77%) cases followed by staph aureus n=
54 (10%). Increase incidence of late onset sepsis (4.6/1000 live births) was
observed during this period. Univariate analysis of risk factors revealed a
significant association between LBW 54 (P value 0.001), prematurity 78 (P
value 0.001) and prolong stay 66 (P value 0.001) and Enterobecter sepsis.
Resistance to the first line antibiotics (Cefotaxime sodium, Aminoglycoside)
was seen in 72% of cases.
Conclusion:
Prolonged stay in the nursery due to prematurity/LBW is
important risk factors of Enterobecter sepsis. Prolonged use of antibiotics
results in emergence of multidrug resistance. Further studies are needed
to establish the role of antibiotics in the emergence of multidrug resistant
microorganism.
Speaker Biography
Zareen Fasih completed her MBBS from Karachi University. She achieved her MRCP
from Royal College of Ireland and was secretary general of Pakistan Pediatric
Association from 2010-2012. She is the Chairperson of Neonatology. She is presently
working as Professor and consultant Neonatologist at Gulf Medical University, UAE.
She has an experience in metabolic and critical congenital cardiac diseases screening
at GMC hospital. She is on the Editorial Board of JppA
e:
zfasih@hotmail.comEmergence of multidrug resistance enterobecter sepsis in a neonatal tertiary care setting: A three
year study
Zareen Fasih, Farhana Zafar
and
Daya Bai
Ziauddin University, Pakistan