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academies
September 20-22, 2017 | Toronto, Canada
10
TH
AMERICAN PEDIATRICS HEALTHCARE &
PEDIATRIC INFECTIOUS DISEASES CONGRESS
Pediatric Healthcare & Pediatric Infections 2017
Introduction:
Association of osteosarcoma with certain
syndromes is well known, but the incidence varies from
one report to another, and from one syndrome to another,
Ruthmond syndrome is the most common syndrome
reported to be associated while others like blackfan
diamond anemia and osteogenesis imperfect are very
rarely associated, and others like osteopoikelosis are never
reported to be associated with Osteosarcoma.
Purpose:
Our aim from this review is to report our experience
and frequency of association of osteosarcoma with
syndromatic features, and to try to see if these syndromes
have effects in the prognosis of osteosarcoma.
Methods:
Retrospectively we reviewed files of all patients
diagnosed with osteosarcoma during the period from
January 2003 till December 2011, information regarding
presence of syndromatic features, current condition of
the patient whether alive or dead or lost and whether had
localized or metastatic disease at diagnosis were recorded.
Results:
During the study period, a total of 69 patients
were diagnosed to have osteosarcoma, six of them were
having syndromes; two were having Ruthmond syndrome,
one blackfan diamond anemia, one cockyne syndrome,
one osteogenesis imperficta and one osteopoikelosis,
constituting 8.7% of all cases. From the 63 non-syndromatic
patients 41 (65%) were having localized disease, 22 (35%)
were metastatic, and from the six syndromatic patients 2
(33.3%) were localized and 4 (66.6%) were metastatic at
diagnosis. Regarding prognosis, from the non-syndromatic
patients 14 were lost for follow up, from the reminder 49
patients, 34 (69.3%) were alive and 15 (30.6%) dead, from
the syndromatic patients, one lost for follow up, one alive
only (20%) and four died (80%).
Conclusions:
Syndromatic features present in 8.7% of our
osteosarcoma patients. Number is small but gives some
evidence about the bad prognosis of osteosarcoma when
associated with syndromes. Further studies needed in this
field.
Speaker Biography
Abdulqader Al-Hebshi has completed his Jordanian and Arab Board in General
Pediatrics in 2010 then he did a Clinical Fellowship in Pediatric Hematology Oncology
for three years from King Hussein Cancer Centre in Jordan. After that he joined The
Hospital For Sick Children in Toronto for another Clinical Fellowship in Pediatric
Hematology and Oncology for the duration of 2014-2015. Currently, he is working
as a Consultant of Hematology and Oncology and the Clinical Supervisor of Medical
Student and Medical Interns at Prince Mohammed Bin Abdul Aziz Hospital-National
Guard Health Affairs in Saudia Arabia. He is an active Member in ASPHO American
Society of Hematology and Oncology.
e:
habshi05@hotmail.comSyndromatic osteosarcoma, does it carry a poor prognosis? King Hussein Cancer Center experience
Abdulqader Al Habshi, Iyad Sultan, Mohammad Al Bohaisi
and
Taleb Ismael
King Hussein Cancer Center, Jordan