11 / 21
Page 28
Notes:
allied
academies
September 20-22, 2017 | Toronto, Canada
10
TH
AMERICAN PEDIATRICS HEALTHCARE &
PEDIATRIC INFECTIOUS DISEASES CONGRESS
Pediatric Healthcare & Pediatric Infections 2017
T
he aim of this study was to evaluate the antiviral activity of rhubarb
extract and emodin on rotavirus R709 strain
in vitro
. The titer and viral
inhibition rate was evaluated for the antiviral activity of rhubarb extract and
emodin in MA-104 cells infected with rotavirus(RV)R709 strain. Meanwhile,
we carried out experiments through the three ways of preventive effect,
virucidal effect, and antiviral biosynthesis effect against RV. The extracts
from rhubarb showed significant inhibitory activity against rotavirus
on MA-104 cells in a dose dependent manner when added at different
stages of viral replication cycles. When added before, during or after viral
infection, the 50% inhibitory concentration (IC
50
) was 101.08±1.57μgmL-
1
,
111.27±4.94μgmL
-1
and 46.88±3.5μgmL
-1
respectively. The therapeutic
index (TI) of rhubarb extract was 3.13±0.13, 3.45±0.06 and 7.45±0.56
respectively. Rhubarb extract was highly active against rotavirus
in vitro
.
However, emodin showed mild antiviral activity.
Speaker Biography
Yang Zhan-qiu has completed his MD from Wuhan University School of Medicine. He
is the Director of Institute of Medical Virology, Wuhan University. He has published
more than 150 papers in reputed journals and has been serving as an Editorial Board
Member of repute.
e:
zqyang@whu.edu.cnAnti-rotavirus activity of rhubarb extract and emodin
in vitro
Yang Zhan-qiu, He Feng-lan, Liu Qiang, Wei Fei, Liu Yuan-yuan
and
Xiong Hai-rong
Wuhan University, China