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September 20-22, 2017 | Toronto, Canada
10
TH
AMERICAN PEDIATRICS HEALTHCARE &
PEDIATRIC INFECTIOUS DISEASES CONGRESS
Pediatric Healthcare & Pediatric Infections 2017
Introduction:
Ad36 is the first human adenovirus reported
that causes obesity in experimentally infected animals and
shows association with obesity in humans. More human
studies, all over the world, are related to the relationship
between Ad36 infection and obesity, and till now have not
been explanatory, studies show contradictory results.
Aim:
The aim of our study is to assess the association
between Ad36 infection and obesity in high-school students
from Eastern Slovakia.
Methods:
Two hundred and twenty-four randomly selected
students (17.72 ± 1.20 years of age, 120 female) from 7 high-
schools in Kosice were included in the study. Subjects with
secondary causes of obesity were excluded and none were
taking medications or had a history of cardiovascular disease.
In 224 healthy students, anthropometric parameters, fasting
plasma glucose and insulin were measured. Ad36 antibody
was detected by ELISA test.
Results:
Serum leptin levels were significantly lower in
presence of Ad36 seropositivity (p<0.05, U=3886.00).
UA levels were significantly higher in Adv36 seropositive
adolescents (318.79 ± 71.51) compared to seronegative
(298.45 ± 63.05) (p<0.05). No significant differences were
found between lean and overweight/obese adolescents in
prevalence of Adv36 seropositivity (chí-kv: 0.60, p=0.43).
Body weight were significantly higher in Adv36 seropositive
lean subjects compared to Adv36 seronegative lean study
group (p<0.05, U=2221.50).
Conclusion:
The current study suggests that Adv36
seropositivity seems to be directly associated with decreased
of leptin levels and development of unhealthy obesity and
cardiovascular (CV) risk, which may be amplified by UA. Our
study shows a possible association between Ad36 infection
and the risk of development of obesity in normal weight
children and adolescents. Further studies in different age
groups of children and adults are required to elucidate this
biological mechanism of such complex relationship.
e:
petra@dodo.skInfections due to various pathogens can lead to overweight and obesity: Adenovirus 36 and obesity
Ingrid Schusterova
1,2
, Alzbeta Tohatyova
1
and Jan Kiraly
3
1
P.J.Safarik University, Slovakia
2
Eastern Heart Institute, Slovakia
3
Veterinary University, Slovakia