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allied
academies
September 20-22, 2017 | Toronto, Canada
10
TH
AMERICAN PEDIATRICS HEALTHCARE &
PEDIATRIC INFECTIOUS DISEASES CONGRESS
Pediatric Healthcare & Pediatric Infections 2017
I
n the origin of schizophrenia the evidences point to intra-
uterine environmental factors that act specifically during
the second pregnancy trimester producing a direct damage
of the brain of the fetus. The current available technology
doesn’t allow observing what is happening at cellular level
since the human brain is not exposed to a direct analysis in
that stage of the life. Methods. In 1977 we began a direct
electron microscopic research of the brain of fetuses at
high risk from schizophrenic mothers in order to finding
differences at cellular level in relation to controls. Results. In
these studies we have observed within the nuclei of neurons
the presence of complete and incomplete viral particles
that reacted in positive form with antibodies to herpes
simplex hominis type I [HSV1] virus, and mitochondria
alterations. Conclusion. The importance of these findings
can have practical applications in the prevention of the
illness keeping in mind its direct relation to the aetiology and
physiopathology of schizophrenia. A study of amniotic fluid
cells in women at risk of having a schizophrenic offspring
is considered. Of being observed the same alterations that
those observed previously in the cells of the brain of the
studied foetuses, it would intend to these women in risk of
having a schizophrenia descendant, previous information
of the results, the voluntary medical interruption of the
pregnancy or an early anti HSV1 viral treatment as preventive
measure of the later development of the illness.
e:
segundo@infomed.sld.cuAbout the etiology of schizophrenia
Segundo Mesa Castillo
Psychiatric Hospital of Havana, Cuba