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Journal of Pathology and Disease Biology | Volume 2
September 06-07, 2018 | Edinburgh, Scotland
Pathology and Surgical Pathology
International Conference on
Trilateral Retinoblastoma: A rare case report
Sai Kumar Maley, Rahul Dev Singh, Uma Nagendra Vishnu, Chanakya Charan Tirumala, Siddartha Reddy Musali
and
Sandeep Lakkarasu
Osmania Medical College, India
T
rilateral retinoblastoma syndrome (TRB) is a rare condition,
it is characterized by intra cranial neoplasm in the pineal
region or Sella/suprasellar region along with a unilateral or a
bilateral retinoblastoma. The intra-cranial neoplasm can occur
after many years in post treatment phase of successfully
treated ocular retinoblastoma. Here we present a case of a
9months old baby girl brought by her mother with complaints
of vomiting, loss of eye contact and one episode of seizure.
On thorough evaluation it was found that both the eyes were
showing leukocoria and fundoscopic examination revealed
tumour in both the eyes. Right fundus showed exudative retinal
detachment and left fundus was not visualized. Subsequent
MRI of brain revealed showed moderately enhancing T1 hypo
& T2 isointense lesions in the posterior aspects of both the
globes; 1.7x0.6cm on right side and 2x1.6cm on the left side
with extension up to optic nerve heads bilaterally and up to lens
on left side noted. Large intensely enhancing suprasellar and
sellar mass measuring 5.4x4.5x4.8cm with focal cystic changes
and calcifications seen exerting mass effect on 3rd ventricle
causing obstructive hydrocephalus. Nodular Dural metastasis
along brainstem cisterns, cerebellar occipital surface and the
spinal canal in the dorso-lumbar region noted. Intra-cranial
mass was partially removed, and the histopathology showed
Homer- Wright rosettes and Flexner Winter Steiner rosettes
and immunohistochemistry w a positive suggesting feature of
retinoblastoma. A possibility of direct intracranial extension
was considered as both the optic nerve heads were involved.
Such kind of cases require a genetic screening, as most of them
are hereditary and harbour a worse prognosis over unilateral
ocular retinoblastoma.
Speaker Biography
Sai Kumar Maley has completed his residency training in pathology and senior
residency from Osmania Medical College. He is interested in research on pulmonary
malignancies and his post-doctoral dissertation work was centered on the
immunocytochemical diagnosis of pulmonary malignancies in low resource setup’s
and his work highlighted an effective and economical usage of immunohistochemical
markers and worked on the preanalytical variables influence on the outcomes.
e:
sai.maley@gmail.com