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J Med Oncl Ther 2017 Volume 2 | Issue 3
International Conference on
Oncology and Cancer Therapeutics
October 30- November 01, 2017 | Chicago, USA
Tumor heterogeneity driven by sharing genetic and signaling code between microbiota and breast
carcinoma
Nilesh Kumar Sharma
Dr. D Y Patil Biotechnology & Bioinformatics Institute, India
There are emerging views to substantiate the inumerable
population of microbioata making their choice of
residence within human body parts including intestine
and mammay glad tissue. In a focussed way, possibly the
presence of microbes in mammar gland could be explained
by the entry of microbes from the skin. There are possibility
of presence of proteobacteria including taxa such as
Bacillus, Acinetobacter, Pseudomonas, Staphylococcus and
Propionibacterium. It is true that presence of these microbes
can impact the normal and tumor mammay glad tissue. In
other way, the role of these microbes may be extended
to possibility that descernible presence of intra-tumoral
heterogeneity in breast tumor could be driven one of
potential routes through microbes and cellular communities
including cancer cell, immune cells and stromal cells. In view
of plethora of microbiot and tumor cellular components
interactions, first elucidation may come from the study of
molecular signaling crosstalk between microbes and tumor
cell. Possibly, molecular signaling crosstalk needs to be
focussed at the level of metabolites secretion and sharing
between microbes and tumor cells. Therefore, metabolome
of tumor tissue needs to be highlighted with reference
to microbes and tumor tissue niches. Another possible
communication between microbes and tumor cell could be
possible through the transfer of genetic materials between
in the form of extra-chromosomal circular DNA like plasmid
and small non-coding RNAs. In this era of science, theer are
evidence of natural transfer of extra-chromosomal circular
DNA and small RNAs may be possible through natural
genetic mateiral exchange process among prokaryotes and
eukaryotes. Hence, one potential question emerges that
whether transfer of microbe origin plasmid with a potential
of drug resistance gene can be transfered to cancer cells
within the tumor niches. These plasmid genetic materials
with drug resistance may be able to confer the reinforcing
capability to the heterogeneous nature of tumor cellular
communities for better growth, suvival and drug resistance.
Currently, we are investigating the contribution of microbiota
mediated plasmid transfer to push tumor heterogeneity.
To achieve this goal, we use next generation sequencing,
metabolomic profiling and molecular techniques. Therefore,
this paper highlight the need for scienetific attempt to
address the interplay of microbes and tumor heterogeneity.
Also precisely unravell the contribution of transfer of drug
resistance plasmid frommicrobes to tumor cell by generating
drug resistant and robust heterogeneous population with
their niches.
Speaker Biography
Nilesh Kumar Sharma has completed his PhD from Indian Institute of Technology
Roorkee, India in the year 2009 within Health Science specialization. He completed
his Post-doctoral research training for more than three years in DNA repair genetic
and cancer biology at NIEHS, NIH, USA and Rutgers University, NJMS, NJ, USA. Since
July 2016, he is working as an Associate Professor at Dr. D Y Patil Biotechnology &
Bioinformatics, Dr. D Y Patil, Vidyapeeth, Pune, India as a faculty and Principal
Investigator in DST and DPU funded research project. He has been credited with more
than 25 research publications in indexed international journals and two book chapters.
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