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Journal of Medical Oncology & Therapeutics | Volume 4
March 18-19, 2019 | London, UK
Oncology & Cancer Therapy
International Conference on
Radiation response of cancer stem cells as predictive marker of radiotherapy efficiency in cervical
cancer patients
Zamulaeva Irina A
A Tsyb Medical Radiological Research Centre, Russia
R
adioresistance of cancer stem cells (CSCs) is considered
as one of the possible causes of cancer recurrence after
radiation therapy. However, little is known about quantitative
changes in CSC subpopulation after radiation exposure
under clinical conditions and association of these changes
with the efficiency of treatment of various malignancies
including squamous cell carcinoma of uterine cervix (SCCUC).
Therefore, the aim of this study was to evaluate changes in
proportion of CSCs in cervical scrape samples from SCCUC
patients after the first few sessions of radiotherapy and
compare these changes with short-term outcomes of the full
course of the treatment including external and intracavitary
irradiation. The degree of tumor regression was assessed
3-6 months after the treatment. Study group consisted of
34 patients at FIGO stages IB-IVA. Informed consent was
obtained from all patients. Proportion of CD44
+
CD24
low
CSCs
was determined by FACS analysis before the treatment and
24 hours after low-LET radiation exposure at a cumulative
dose of 10 Gy to point A. Postradiation decrease in the
CSC proportion was associated with the complete tumor
regression, while increase – with the partial regression.
Thus, the frequency of the partial tumor regression was
5,6-fold higher in patients with postradiation increase in the
CSC proportion than in other patients who demonstrated
decrease in this indicator (p=0.04, AUC=0.73). The results
demonstrated predictive value of individual radiation
response of the CSC population for short-term outcomes of
SCCUC treatment.
This work was supported by grant of Russian Scientific
Foundation # 18-75-10025.
Speaker Biography
Zamulaeva Irina A has completed her PhD at the age of 32 years fromMedical Radiological
ResearchCentre,Russia.She isprofessorandHeadofDepartmentofRadiationBiochemistry
of Medical Radiological Research Centre. She has over 140 publications (in English and
Russian) that have been cited over 600 times, and her publication H-index is 11 according
to Russian Science Citation Index. She has been serving as an editorial board member of
reputed Journals.
e
:
zamulaeva@mail.ru