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Journal of Medical Oncology & Therapeutics | Volume 4
March 18-19, 2019 | London, UK
Oncology & Cancer Therapy
International Conference on
Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumours at some selected hospital in Ghana
Precious Barnes
University of Cape Coast, Ghana
Background
: Head and neck cancers (HNC) are cancers of
the paranasal sinuses, the salivary glands and the upper
aero¬digestive tract. RIN1 is a Ras effector protein regulating
epithelial cell properties and has been implicated in a
number of cancers.
Method
: The aim of this study was to investigate the
expression of RIN1 in head and neck tumour. RIN1 expression
was analyzed using quantitative real-time PCR (qRT-PCR)
and immunohistochemical staining on tissue samples from
a consecutive series of 150 head and neck tumour patients
who underwent tumor resections between 2014 and 2017.
Results
: The relationship between RIN1 expressions,
clinicopathological factors, was investigated. qRT-PCR results
showed that the RIN1 mRNA expression was low in tumor
tissue samples than in RIN1 expression were low as compared
with the normal head and neck tissues. High and lowRin 1was
compared with ages ≤40, >40 in the head and neck cancer of
p- value 0.02. There was a significant difference between the
histological differentiation of the magninant tumour with p
values of 0.001, when poor andwell moderatewas compared.
Conclusion
: Our data suggest that RIN1 plays an important
role in head and neck tumour progression and that
its expression will provide baseline data to facilitate
identification of new molecular targeting therapeutics.
e:
p.barnes@uccsms.edu.gh