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J Med Oncl Ther 2017 | Volume 2 Issue 4
Oncology and Biomarkers Summit
November 27-28, 2017 | Atlanta, USA
Annual Congress on
Non-correlation between tumor biomarkers levels in peritoneal carcinomatosis
Manuela Stoicescu
University of Oradea, Romania
Introduction:
Peritoneal carcinomatosis is considered the
end stage of cancer, with different locations. Disseminations
of metastases in peritoneumare very dangerous; because the
invasion is extended from the primary tumor to peritoneum.
Of course, we expect that in this advance stage of cancer the
levels of tumor biomarkers to be increase or very increase, in
concordance with the severity of the disease.
Material & Methods:
Present the situation of a woman
patient 73 years old, who suffered a total hysterectomy with
bilateral oophorectomy, with one year a half before, for
carcinoma of the uterus. The patient refuses radiotherapy
and chemotherapy after surgical intervention. After this
period of time develop sudden a clinical picture of occlusion
of the bowel. An abdominal CT was performed and surprise
put in evidence a tumor block in right flank, around the
ascendant colon and catch also a few anses of small bowel
and fluid collection inside of peritoneal cavity around the
liver and around the spleen in medium quantity. The patient
suffered surgical intervention, but the tumor block wasn’t
possible to be removed, was performed only a palliative
surgical intervention with ileostoma (contra nature anus),
drainage of fluid of as cites and resection of omentum.
The analyses of fluid confirmed neoplastic etiology and
histopathology examination from omentum confirmed
metastases in omentum. After laparotomy, the surgeon
observes peritoneal carcinomatosis. The problem was
that all the tumors biomarkers performed before surgical
intervention were in normal range: CE (carcinoma embryonic
antigen) <0,50 ng/mL, feto protein<0,97 ng/mL, CA125<0,5
U/mL, SCC (Squamous Cell Carcinoma) =0,8 ng/mL (normal
range<1,5).
Results & Discussions:
The most important question is, how
was possible to be in normal range all these tumor markers
in context of peritoneal carcinomatosis – the end stage of
cancer? Confer us safe the normal results of level of tumor
markers that the patient isn’t in danger or in advance stage
of cancer?
Conclusion:
Themost important conclusion of this presentation
is that exist paradoxes a non-correlation between the tumor
biomarkers levels and peritoneal carcinomatosis.
Speaker Biography
Manuela Stoicescu is a Assistant professor in University of Oradea, Romania. She
has completed her Phd in 2010. She has published various books and was invited as
speaker for 12 International Conferences. She is the Member of Romanian Society of
Internal Medicine and Romanian Society of Cardiology. Member of Balcanic Society of
Medicine. She has published many articles.
e:
manuela_stoicescu@yahoo.com