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J Med Oncl Ther 2017 | Volume 2 Issue 4
Oncology and Biomarkers Summit
November 27-28, 2017 | Atlanta, USA
Annual Congress on
Circular BANP expression profile and potential function in human colorectal cancer
Feng Yan
Nanjing Medical University, China
C
ircular RNAs (circRNAs) are recently identified as
widespread and diverse endogenous noncoding RNAs
that may harbor vital functions in human and animals.
However, the role of circRNAs in the process of tumorigenesis
and development of colorectal cancer (CRC) remains vague.
Here, we characterized the circRNA expression profile from
three paired CRC cancerous and adjacent normal tissues
by human circRNA array and identified 136 significantly
overexpressed circRNAs (>2-fold changes). We further
validated one circRNA generated from Exon 5-11 of BANP
gene, termed circ-BANP. In addition, RT-PCR result showed
that circ-BANP was overexpressed in 35 CRC cancerous
tissues. Knockdown of circ-BANP with siRNA significantly
attenuate the proliferation of CRC cells. In summary, our
findings demonstrated that dysregulated circ-BANP appears
to have an important role in CRC cells and could serve as a
prognostic and therapeutic marker for CRC.
Speaker Biography
Feng Yan is the Vice Director of Department of Clinical Laboratory in Nanjing Medical
University Affiliated Cancer Hospital and Jiangsu Cancer Hospital. The research works
focus on the Bioanalytical Chemistry in laboratory medical diagnostics, particularly in
detection of tumor markers and tumor cells. She has published 42 papers in Scientific
journals. She was the Outstanding Medical Talents, Excellent Medical Talent and
Leading Medical Talent of Jiangsu Province.
e:
yanfeng1895@163.com