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Nov 12-13, 2018 | Paris, France
Joint Event
Nutraceuticals and Food Sciences
International Conference on 27th International Conference on
Nursing and Healthcare &
Journal of Food science and Nutrition | Volume 1
This presentation reviews recent research which has given
us new insights into the molecular biology of extrinsic
aging of the skin. Not only does UV (ultraviolet) irradiation
directly cause photoaging of the skin, but also environmental
pollutants significantly damage exposed skin by several
mechanisms. Exposure to the noxious gases of air pollution
with simultaneous exposure to UVA can act synergistically
to accelerate photoaging and to initiate skin cancer. Also,
ozone generated from pollutants reacting with UV induces
oxidative stress of the skin’s surface via formation of lipid
peroxidation products, with cascading consequences to
deeper layers. Furthermore, new studies have demonstrated
that particulate matter (PM) pollutants can penetrate the
skin transepidermally and through hair follicles to induce
skin aging via the aryl hydrocarbon receptor (AHR), a
recently discovered ligand-activated transcription factor
that regulates and protects keratinocytes, melanocytes,
and fibroblasts. With this understanding that extrinsic
aging of the skin is not only due to photoaging, we realize
the necessity of protection beyond sunscreen. Fortunately,
correctly formulated topical antioxidants can prevent
damage inflicted by both UV and environmental pollution.
The stringent requirements to achieve stability, penetration,
and activity of these effective antioxidants will be described.
Speaker Biography
Karen Burke is a dermatologist and research scientist. After her Ph.D. in biophysics
from Cornell University, Ithaca, NY, she completed post-doctoral fellowships at Cornell
University Medical College and The Rockefeller University. She earned her M.D. at New
York University with residency in dermatology. She is currently an Associate Clinical
Professor in the Department
She has written many research articles and medical book review chapters as well as six
popular books (including Thin Thighs for Life, Great Skin for Life, and Thin Thighs Diet and
Workout). She is often quoted as a skincare expert in many fashion and health magazines.
She currently serves on the editorial boards of Cutis, Aesthetic Dermatology News, Cosmetics
in Dermatology, and Journal of Drugs in Dermatology. For many years, she was the Medical
and Science Editor of the DiplomaticWorld Bulletin (United Nations, New York) for which she
wrote a monthly “Health Update” column. She has been a consultant to many corporations
includingL’Oréal(Paris,France).ShehasbeencitedasoneofNewYork’sprominentphysicians
by New York Magazine and The New York Times and by Castle-Connolly Guide to Doctors
each year since 2001. She received a “Women of the Year” award from the New York Police
Athletic League (2009), a “DistinguishedWoman Award” fromNorthwood University (2010),
and a “Trademark Woman of Distinction Honor” (2017). In 2014 she received a Presidential
Citation from the American Academy of Dermatology and was elected to the prestigious
American Dermatological Association (and to the ADA Board in 2017).
She is an Honorary Life Governor of the New York Academy of Sciences and serves on
the Board of Directors of the New York Stem Cell Foundation and the Parkinson’s Disease
Foundation, and is a Trustee of the Poly Prep Country Day School. She has also served on
to the United States Federal Drug Administration (FDA) General and Plastic Surgery Device
Advisory Panelsince 2007. She is founder and president of the Karen E. Burke Research
Foundation and of Longévité, Ltd. She was previously on the Board of the Women’s
Dermatologic Society and is still active in that organization. She serves on the board of the
Hospitality Committee for UN Delegates and is an active member of the Women’s Forum
of the United Nations and One Bright World as well as of many scientific and medical
organizations including the American Academy of Dermatology, the Skin Cancer Foundation,
The Dermatology Foundation, the American Society of Dermatologic Surgery, the Society for
Investigative Dermatology, and the American Medical Association, and others.
e:
Karen E Burke
Mount Sinai Medical Centre, USA
Prevention of environmental damage to the skin by topical antioxidants