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academies
Volume 2
June 11-13, 2018 | London, UK
Neurology and Neuroscience
6
th
International Conference on
Dementia is a disease of the ependymal layer: Novel theory from looking at cognitive impairment in
Multiple Sclerosis
Philip A McMillan
Doncaster and Bassetlaw NHS Trust, UK
T
he intricacies of dementia are explored in relation to varied
studies on brain atrophy in multiple sclerosis and used
to delineate the primary pathology of the latter. The theory
examines the high frequency of cognitive impairment (Jongen
2012) in Multiple Sclerosis and its early manifestation during
the disease. The fact that there is associated brain atrophy
cannot be explained by the degree of damage to neurons.
(Carlos 2015) noted a 5 to 10 times greater rate of atrophy in
Multiple Sclerosis. The cognitive changeswithMultiple Sclerosis
are then correlated embryologically to the subependymal
zone (Kazanis 2009) explaining the pathology of brain atrophy
and why we have not made more progress through research.
Our understanding of the blood CSF barrier and the brain CSF
interaction is poorly understood and probably holds the key
to the symptoms of dementia (Erikson 2013). This interaction
between the CSF and brain interstitial space is coordinated by
the ependymal and subependymal zone of the brain. This is
a novel concept that will aim to explain the links of all forms
of dementia, as well as directing fertile areas for research.
Speaker Biography
Philip A McMillan is a Consultant in the NHS with over 23 years of medical expertise.
His primary focus has been around Geriatrics and Neurological Rehabilitation
and has developed unique perspectives on the capacity of the brain to recover
from injuries and disease. Through international collaboration he has proposed
a nutritional protocol for dementia reversal and has recently had a breakthrough
theory on the pathology of dementia. His current aim is to lead the field of
dementia to a new direction of research and treatment of this devastating disease.
e:
philip.mcmillan@nhs.net