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Journal of Neurology and Neurorehabilitation Research | Volume 3
August 23-24, 2018 | Paris, France
Neurology and Neurological Disorders
18
th
International Conference on
Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity
in children with Autism Spectrum disorders
Elham Mousavinejad
Ahvaz Jundishapur University of Medical Sciences, Iran
A
ntioxidants and oxidative stress can participate in
pathobiochemical mechanisms of autism spectrum
disorders (ASDs). The aim was to identify the effects of early
CoQ10 supplementation on oxidative stress in children with
ASDs. Ninety children with ASDs were included in this study,
based on DSM-IV criteria and using Childhood Autism Rating
Scale (CARS) scores. Concentrations of CoQ10, MDA, total
antioxidant status (TAS) assay, and antioxidant enzymes
(superoxide dismutase or SOD and glutathione peroxidase or
GPx) activity were determined in serum before and after 100
days of supportive therapy with CoQ10 at daily doses of 30 and
60 mg. Data on children’s behavior were collected from parents
and babysitters. CoQ10 supportive therapy was determined
after three months with daily dose 2 ͯ30 mg improved oxidative
stress in the children with ASDs. A relation was seen between
serum MDA (r2 = 0.668) and TAS (r2 = 0.007), and antioxidant
enzymes (SOD [r2 = 0.01] andGPx [r2 = 0.001]) activity andCARS
score. Based on the results, high doses of CoQ10 can improve
gastrointestinal problems (P = 0.004) and sleep disorders (P =
0.005) in childrenwithASDswithan increase in theCoQ10of the
serum. We concluded that the serum concentration of CoQ10
and oxidative stress could be used as relevant biomarkers in
helping the improvement of ASDs.
Speaker Biography
Elham Mousavinejad has completed her MSc in the Department of Biochemistry, School
of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, in 2016, and BSc
Degree in Community Nutrition, School of Nutritional Sciences and Dietetics, Jundishapur
University of Medical Sciences, Ahvaz, Iran in 2006. Her research area involved Nutritional
Neuroscience and various nutritional deficiencies described in children with ASDs.
e:
mousavinejad.e@ajums.ac.ir