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allied

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Journal of Neurology and Neurorehabilitation Research | Volume 3

August 23-24, 2018 | Paris, France

Neurology and Neurological Disorders

18

th

International Conference on

Chronic stress and moderate exercise prompt widespread common activation and limited differential

activation in specific brain regions

Tae-Kyung Kim

1,2,

Seung-Jae Lee

1,

and

Pyung-Lim Han

2

1

Seoul National University College of Medicine, South Korea

2

Ewha Woman’s University, South Korea

C

hronic stress in rodents produces depressive behaviors,

whereas moderate exercise counteracts stress-induced

depressive behaviors. Stress and exercise appear to produce

such opposing effects by changing the neural activity of specific

brain regions. However, the detailed mechanisms through

which the two different types of stimuli regulate brain function

in opposite directions are not clearly understood. In the present

study, we attempted to explore the neuroanatomical substrates

mediating stress-induced depressive behavioral changes and

anti-depressant effects of exercise by examining stimulus-

dependent c-Fos induction in the brains of mice that were

exposed to repeated stress or exercise in a scheduled manner.

Systematic and integrated analyses of c-Fos expression profiles

indicated that various brain areas, including the prelimbic

cortex (PrL), parietal cortex (PaC), lateral septal nucleus (LS), and

paraventricular nuclei of hypothalamus (PVN) were commonly

and strongly activated by both stress and exercise, while the

habenula (HB) and hippocampus (HP) were identified as being

preferentially activated by stress and exercise, respectively.

Exercise-dependent c-Fos expression in all regions examined

in the brain occurred in both glutamatergic and GABAergic

neurons. These results suggest that chronic stress andmoderate

exercise produce counteractive effects on mood behaviors,

along with prompting widespread common activation and

limited differential activation in specific brain regions.

Speaker Biography

Tae-Kyung Kim graduated from Korea University in South Korea with a bachelor’s

degree in biology. During graduate study at Rutgers University (Robert Wood

Johnson Medical School), he studied the molecular mechanisms and regulation

of eukaryotic gene expression under the supervision of Dr. Danny Reinberg (HHMI,

currently at NYU). After obtaining a PhD degree in Biochemistry, he continued

his research career in the laboratory of Dr. Michael Greenberg (Harvard Medical

School) as a postdoctoral fellow, studying how neuronal activity controls gene

expression in neurons to mediate synapse remodeling and plasticity. He joined

the faculty in the Department of Neuroscience at UT Southwestern in 2010.

e:

spt21@hanmail.net