10 / 25
Page 46
Notes:
allied
academies
Journal of Neurology and Neurorehabilitation Research | Volume 3
August 23-24, 2018 | Paris, France
Neurology and Neurological Disorders
18
th
International Conference on
A systematic review of antiepileptic drug randomised control trials over 20 years
Elkie Ben Hur
University of Liverpool Medical School, UK
E
pilepsy is a neurological condition which manifests
itself by causing alterations in the brain and this leads
to seizures. Seizures can affect people in many ways and
therefore anti-epileptic drug management is a key part to
these people’s lives. The guidelines on the use of antiepileptic
drugs are derived from randomised control trials undertaken
on these medications. The aim of the paper was to assess
and evaluate antiepileptic drug RCTs over the past 20 years.
A database search was conducted and from this, data was
extracted via double data extraction. A total of 148 trials
from the years 1995-2015 were analysed and included in our
systematic review. Papers were scrutinised by identifying
types of patients included in trials, types of methods that
trials conducted, and the outcomes measured from these.
After interpreting results, from the majority of studies it was
evident that documentation of clinical trials did not meet the
CONSORT guidelines for what information to include in RCTs
and therefore more care should be taken when writing trial
reports in future as treatment decisions are based on these
trials.
e:
elkie_b_h@hotmail.co.uk