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Biol Med Case Rep 2017 | Volume 1 Issue 2
November 06-07, 2017 | New Orleans, USA
Nanomedicine & Healthcare
Global Meet on
Fabrication and evaluation of nanofibrous biomaterials for biomedical applications
Lina Fu
University of Nebraska Medical Center, USA
B
acterial nanocellulose (BC), a natural three-dimensional
nano-biomaterial fabricated via microbial fermentation
with a primary fiber diameter of ~14nm, distinguishes itself
fromcellulose derived fromother sourcesmainly by its purity,
crystallinity, mechanical strength, three dimensionalities,
high water holding capacity, and good biocompatibility. BC
has found many biomedical applications such as bioscaffolds
in the repair and regeneration of skin, blood vessel, cornea,
heart valve prosthesis, urethra, nerve, bone, cartilage and
knee menisci, as well as for the delivery of drugs, hormones
and proteins. A combined method to control the thickness of
the BC film was a part of my research. BC was biosynthesized
by gluconacetobacter xylinus (ATCC53582) and modified by
chitosan. The nano-composites of BC and chitosan form a
cohesive gel structure, and the cell toxicity of the composite
is excellent. A novel strain could reduce the cost of BC
production and accelerate the manufacturing process of
wound dressings and antimicrobial wound healing products
from this novel strain. With different oxygen availability
and different biofabrication parameters, microbes can
produce BC in forms of hydrogel and that can be processed
to different forms as film, tube, sphere and nanocrystal.
Incorporation of reactive functional groups and nanosilver
particles into the polymer backbone via heterogeneous surface
reactions can be used as delivery platforms frombiosynthesized
nanofibers using microbes to synthesize nanofibers using
electrospinning. My focuses aim to heal damaged skin tissues
and can also applied in other fields in tissue engineering and
nanomedicine.
Speaker Biography
Lina Fu received her Ph.D. degree in Microbiology from Department of Biomedical
Engineering, Huazhong University of Science and Technology, China. Upon the
completion of MITACS Accelerate Internships and Postdoctoral Fellow in Western
University and Axcelon Biopolymer Corporation, Canada, she started doing the
postdoctoral research in Mary & Dick Holland Regenerative Medicine Program,
University of Nebraska Medical Center, USA. Her work resulted in 5 peer-reviewed
publications, 2 book chapters and 1 issued innovation patent and has been cited over
300 times since 2012. She was awarded the MITACS Accelerate Awards from 2014
to 2016. She serves as the reviewers for Advanced Functional Materials, Journal of
Materials Chemistry A, Nanoscale, Chemical Communications, Acta Biomaterialia,
Biofabrication, Oncotarget and Carbohydrate Polymers. She is also a member of
professional scientific organizations including BMES, CBS, ACS and RSC. Fu has had
more than ten years’ experience in biomaterials and polymers, in terms of hydrogel,
electrospun fibers, film, sponge, 3D printed materials, elastomer, microspheres and
nanoparticles, etc. Her research is focused on engineering bacterial nanocellulose
based materials and the use of a combination of cells/tissues, as well as suitable
biochemical and physical cues to restore, maintain, or improve biological functions of
damaged/diseased tissues or organs.
e:
lina.fu@unmc.edu