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Biol Med Case Rep 2017 | Volume 1 Issue 2
November 06-07, 2017 | New Orleans, USA
Nanomedicine & Healthcare
Global Meet on
Nanofluorophore assisted fluorescence image-guided cancer surgery
Jian Xu
Louisiana State University, USA
S
urgical resection is still the major treatment for solid tumors.
The complete surgical resection of the cancer tissues in
the surgery is essential to the prognosis of cancer patients.
However, 40% of the US patients have the local recurrence
in 5 years from the initial surgery, due to the failure to detect
all the cancer tissues intraoperatively. In the surgery, in case
of uncertainty, the surgeon may take biopsies and send for
the frozen section procedure. This pathological procedure
is expensive and inefficient: it may take 20-30 min, while
keeping the patient under anesthesia; due to the non-optimal
preparation of the tissues, the diagnosis accuracy is lower than
“formalin fixed paraffin embedded tissue procedure”. The latter
procedure takes even longer time (several hours to days after
the surgery) to obtain the diagnosis result. Our lab developed
an imaging system, together with ICG-protein complex as nano-
imaging contrast agent, to help the intraoperative diagnosis of
tissues. We have conducted dozens of clinical trials on human
pancreatic cancer in major hospitals in USA. Over two hundred
sample tissues from various pancreatic cancer surgeries,
including distal pancreatectomy, whipple procedure, and total
pancreatectomy, were inspected with our imaging system.
Within one sec, our device can quantitatively differentiate
cancerous tissues from non-cancerous tissues intraoperatively:
Primary tumor and positive margins showed more than 200%
stronger ICG fluorescence than normal tissues and negative
margins did. The overall diagnosis accuracy of cancer by our
system is 94.9%.
Speaker Biography
Jian Xu is currently an Assistant Professor in the Division of Electrical and Computer
Engineering at Louisiana State University, USA. He has received his PhD degree in
Engineering from the Yale University, USA. His work has been published on well-
recognized journals (e.g.
Nature Nanotechnology
(IF: 38.986),
Advanced Materials
(IF:
19.791), and
SoftMatter
) and widely reported by international media (e.g. Süddeutsche
Zeitung-the largest newspaper in Germany, the Economist, and Science Daily). He is a
reviewer of IEEE transactions on biomedical engineering, IEEE international symposium
on circuits and systems, Full Member of Sigma Xi, and so on. His research interests
include biomedical instrumentation for image-guided surgery and biomimetic energy
harvesting scheme with bio-nano electronics. His medical devices have been put into
clinical trials in several major hospitals in US.
e:
jianxu1@lsu.edu