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Biol Med Case Rep 2017 | Volume 1 Issue 2

November 06-07, 2017 | New Orleans, USA

Nanomedicine & Healthcare

Global Meet on

Polymeric micellar paclitaxel: Approval challenges and lessons learned

Kouros Motamed

NantBioscience, Inc., USA

ynviloq™ (Genexol-PM®), a non-biologic micellar formulation

of paclitaxel, utilizes biodegradable di-block copolymers

composed of methoxy poly (ethylene glycol)-poly (lactide) to form

micellar nanoparticles with paclitaxel containing a hydrophobic

core and a hydrophilic shell and is being developed as the next

generation nanoparticle paclitaxel. Its target indications are solid

tumors such as metastatic breast cancer, lung, ovarian, bladder,

pancreatic and melanoma. Herein, we discuss challenges faced

and lessons learned from a PK bioequivalence trial of Cynviloq vs.

the FDA approved nanoparticle albumin-bound (nab)-paclitaxel

(Abraxane®).

Speaker Biography

Kouros Motamed has been the Director of Drug Development at NantBioScience,

Inc. since April 2016. Prior to that, he has served as VP of Strategic Alliances and

Clinical Communications and VP of Clinical Development and Nanomedicine at

Sorrento Therapeutics from 2013 to 2016. He has also served as a Co-Founder and

CSO/CTO of Igdrasol, Inc. and Biomiga Diagnostics start-up companies from 2011-

2013. Prior to that, he has served as the MOA and Molecular Biology Group Head at

Celgene Corp. and Abraxis BioScience Inc. from 2007-2011. He has held an Assistant

Professorship position in the Department of Pathology and Vascular Biology Center

at Georgia Health Sciences University from 2002-2007. He has over 30 original

publications in peer-reviewed journals, over 50 conference presentations and has 5

issued patents. He has served on the Editorial Board of

Journal of Nanomaterials and

Molecular Nanotechnology

since 2013. He has received his BS degree in Biology from

University of San Francisco and a PhD degree from the University of California, Davis

in Microbiology.