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Journal of Biomedical Research | Volume: 29
November 19-20, 2018 | Paris, France
Molecular Biology, Tissue Science and Regenerative Medicine
International Conference on
Joint Event
&
4
th
World Heart Congress
Silicosis-induced fibrosis: Pathogenesis, intervention and treatment
D Cheng Peng
Queensland Alliance for Environmental Health Sciences, Australia
L
ongtermexposuretosilicacaninducesilicosis,aglobedisease
with higher incidence in developing countries. Although
extensive efforts have been made, the molecular mechanisms
remain to be fully elucidated for this disease. It is believed that
the general process of the lung fibrosis includes the cell damage,
formation inflammation, epithelial mesenchymal transition
(EMT), extra cellular matrix and collagen deposition and
consequent fibrosis. Due to the pathogenic complexity of the
disease, togetherwith the irreversibility of the fibrosis, silicosis is
currently a progressive and incurable disease. Pharmacological
treatment methods targeting on above process have been
proved to be largely unsatisfactory. As an emerging treatment
protocol, cell therapy through stem cell transplantation is
promising in treatment of many disease including lung fibrosis.
In this talk, the molecular mechanisms of silicosis, current
treatment and our work to investigate the intervention effects
of stem cells from various sources on the formation and
development and lung fibrosis inanimalmodelwill bediscussed.
e:
c.peng@uq.edu.auMolecular Biology & Heart Congress 2018, Volume 29
DOI: 10.4066/biomedicalresearch-C8-023