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Journal of Biomedical Research | Volume: 29

November 19-20, 2018 | Paris, France

Molecular Biology, Tissue Science and Regenerative Medicine

International Conference on

Joint Event

World Heart Congress

The validationof hla-b*13:01 as genetic biomarker of trichloroethylene-inducedhypersensitivity syndrome

in a prospective cohort study

Qiang Jia

Shandong Academy of Medical Sciences, China

richloroethylene (TCE)-induced hypersensitivity syndrome

(HS) has become one of the serious public health issues.

Previous case-control study found that HLA-B*13:01 is a high-

risk marker of TCE-induced HS (TCE-HS) with odds ratio of 27.5.

This study aimed to validateHLA-B*13:01 as a genetic biomarker

of TCE-HS and evaluate its effectiveness for screening TCE-HS in

population occupationally exposed to TCE, for which 1,764 new

workers firstly exposed to TCE were enrolled in this prospective

cohort study. During the three-month period of follow-up, 16

patients were found with the incidence of TCE-HS being 0.97%.

Based on genotyping of HLA-B, the study subjects were divided

into HLA-B*13:01 positive group and negative group. We found

the incidence of HS was 7.59% in HLA-B*13:01 carriers and

0.27% in non-carriers of HLA-B*13:01. The relative risk (RR)

is as high as 28.35 (95% CI: 9.25 to 86.85). Receiver operating

characteristic curve analysis showed that HLA-B*13:01 allele

screening yielded an area under curve (AUC) of 0.83 with

sensitivity of 75% and specificity of 91.1% in discriminating

TCE-HS. The study firstly reported the incidence of TCE-HS in

southern Chinese population and validated HLA-B*13:01 as a

susceptible biomarker in TCE-exposed cohort. The effectiveness

analysis highlighted that HLA-B*13:01 allele screening is a cost-

effective means in prevention of TCE-HS among TCE-exposed

workers.

Speaker Biography

Qiang Jia is now currently working in Key Laboratory of Chemical Safety and Health,

National Institute for Occupational Health and Poison Control, Chinese Centre for Disease

Control and Prevention, Beijing, China and also in Shandong Academy of Occupational

Health and Occupational Medicine, Shandong Academy of Medical Sciences, Shandong,

China.

Qiang Jia, Molecular Biology & Heart Congress 2018, Volume 29

DOI: 10.4066/biomedicalresearch-C8-023