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Volume 2, Issue 3 2017
Journal of Medical Oncology and Therapeutics
Dermatologists & Melanoma 2017
August 31-September 01, 2017
Page 79
&
2
nd
Euro-Global Congress on
August 31-September 01, 2017 London, UK
12
th
Global Dermatologists Congress
Melanoma and Skin Diseases
Electrical signaling in epithelial migration
Min Zhao
University of California at Davis, USA
E
pithelia, such as skin are seldom considered to have any electrical activities. However, live polarized epithelia–epidermis
for example does maintain electrical potential difference, normally apical negative and basal side positive. This electrical
feature has been known over many decays and is named trans-epithelial potential difference (TEP). Whether the TEP has any
significant functions in epithelial biology remain to be less well studied and understood. Research in the past decades provide
compelling experimental evidences suggesting significant roles for the TEP in epithelial polarization, migration and wound
healing. We have demonstrated the electrical feature of epithelial tissues and some of the molecular mechanisms as well as the
overriding guidance effects of electrical signaling in cell polarization, guidance effects of electric fields in cell migration, and
tissue growth in wound healing and finally some exciting and new understanding of how epithelial cells sense and respond
to electrical stimulation. My presentation will draw attention of audience to this potentially important aspect of electrical
signaling at tissue level in skin biology and implications in melanoma and skin diseases.
minzhao@ucdavis.eduJ Med Oncl Ther 2017, 2:3