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Volume 2, Issue 3 2017
Journal of Medical Oncology and Therapeutics
Dermatologists & Melanoma 2017
August 31-September 01, 2017
Page 76
&
2
nd
Euro-Global Congress on
August 31-September 01, 2017 London, UK
12
th
Global Dermatologists Congress
Melanoma and Skin Diseases
Dysplastic nevi, cutaneous melanoma and other skin neoplasms in patients with myotonic dystrophy
type 1: a cross-sectional study
Zampetti A
1
, Manco S
1
, Masciullo M
1
, Santoro M
2
, Bewley A
3
, Feliciani C
1
and
Silvestri G
1
1
Catholic University of Rome, Italy
2
Don Carlo Gnocchi Foundation Organizzazione, Italy
3
Barts NHS Trust, UK
M
yotonic dystrophy type 1 (MD1) is reported to be associated with internal malignancies. The association of myotonic
dystrophy with cutaneous tumors is not fully understood. We sought to explore the total nevi count and the presence
of atypical nevi, cutaneous melanoma, and other skin neoplasms in a representative cohort of patients with MD1 and to
compare the findings with age- and sex-matched control subjects. In all, 90 patients with MD1 and 103 age- and sex-matched
control subjects were assessed for cutaneous neoplasms by clinical skin and epiluminescence examination (dermoscopy).
Where indicated, subsequent excisions were performed. In patients with MD1, leukocyte n (CTG) expansion was measured.
Patients with MD1 showed significantly higher numbers of nevi, dysplastic nevi and melanomas despite a significantly greater
proportion of the control subjects reporting sunburns. In addition, we found a significantly greater number of pilomatrixoma
in patients with MD1. Our study is limited by the fact that there is no agreed-upon standardized technique to assess for
prior sun exposure. Further research in the association of cutaneous neoplasms and MD1 including vitamin D and molecular
biological techniques are also recommended. MD1 itself may predispose to development of skin tumors.
anna.zampetti@gmail.comJ Med Oncl Ther 2017, 2:3