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Volume 2, Issue 3 2017
Journal of Medical Oncology and Therapeutics
Dermatologists & Melanoma 2017
August 31-September 01, 2017
Page 80
&
2
nd
Euro-Global Congress on
August 31-September 01, 2017 London, UK
12
th
Global Dermatologists Congress
Melanoma and Skin Diseases
Cryo-carboxy surgery, a new armamentarium in aesthetic treatment of difficult mutilating nasal
hairy mole
Nader Elmelegy
Tanta University, Egypt
A
n Egyptian papyrus document describes the use of cold as an anti- inflammatory, and Hippocrates, back in fifth century
BC, recommended cold for reducing bleeding, bruising, and swelling. Cryosurgery technique involves performance of
one or more freeze-thaw cycles. This causes tissue damage, vascular stasis and inflammatory response upon freezing a certain
area with cryospray or cryoprobe. Furthermore, organization of polar water molecules into a clathrate around proteins will
facilitate cold denaturation. In these conditions, protein loses its tertiary structure or three-dimensional shape, because non-
covalent hydrophobic bonds are ruptured. Upon losing its tertiary structure, the protein is no longer able to perform its
functions including the enzymatic ones.
In vivo
research of mouse oocytes has established that if tissue temperature is above-
40°C, then formation of the intracellular is directly dependent on frozen extracellular water fraction. For intracellular crystals
start to form, 94 % or more volume of extracellular water would have to be frozen. Hairy moles cause severe aesthetic and
psychological problems to their patients. Many traditional techniques have been used as, skin graft, local flaps, distant flaps
and free flaps. All results are unsatisfactory. Also laser, chemical peel and local medical treatment have been used with less
acceptable results. In this work we are going to present, a new line for treatment with the use of cryo-carboxy surgery for
treatment of nasal hairy moles in 20 patients. The results are so excellent to the degree that we consider it will be the future
treatment of such lesions. Patients were so happy with the results, as in those cases no destruction of the local tissues. We will
present this new technique and present our clinical cases
naderelmelegy@gmail.comJ Med Oncl Ther 2017, 2:3