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Journal of Systems Biology & Proteome Research
|
Volume 2
J u n e 2 5 - 2 7 , 2 0 1 8 | D u b l i n , I r e l a n d
MASS SPECTROMETRY
AND PROTEOMICS
International Conference on
ABUSE DRUGS BY GAS CHROMATOGRAPHY MASS
SPECTRUM
Raafat Abdeldayem
Mansoura University, Egypt
Background:
Drugs of abuse are any drug or substance which if taken by any route (oral-snuffing-injection) will lead to mood
change, psychological disturbance and can affect brain functions and level of perception. The aim of this work is to evaluate the
usefulness of using urine immunoassay kits for detection of some drugs of abuse, and study the correlation between the results
obtained by EMIT and GC / MS techniques.
Materials & Methods:
Drug toxicology tests are most commonly performed on urine, since most drugs and their breakdown
products are excreted in the urine at higher concentration. A total number of 449 inhabitant urine samples were collected from
patients admitted to emergency hospital, Mansoura University. 449 urine samples were analyzed by EMIT and GC / MS for
benzodiazepine, barbiturate, opiate and cannabinoid.
Results:
Revealed that urine immunoassay kit is useful for rapid preliminary screening of abuse drug. GC / MS results confirm
that 245 samples (54.56 %) are positive of the total number of samples. These positive samples by GC / MS were as follows;
benzodiazepines; 159 ((clonazepam, oxazepam, temazepam), barbiturates; 58 (thiobarbiturate, butabarbital, seconal) and
opiates; 28 (methadone metabolite)).
Conclusions & Recommendations:
GC / MS analysis must be done for accurate identification and confirmation of EMIT results. In
addition, it is recommended as the most suitable technique for obtaining optimum analytical results.
Keywords;
Urine samples, EMIT, GC/MS.
raafat_mandour@hotmail.comJ Syst Biol Proteome Res 2018, Volume 2