13 / 14
allied
academies
Page 27
International Journal of Respiratory Medicine
|
Volume 3
LUNG CANCER AND COPD
5
th
International Congress on
J u n e 2 5 - 2 6 , 2 0 1 8 | A m s t e r d a m , N e t h e r l a n d s
Rabindra Nath Das, Int J Respir Med 2018, Volume 3
FORCED EXPIRATORY VOLUME
FACTORS OF STAGE III NON-SMALL
CELL LUNG CANCER PATIENTS
Rabindra Nath Das
University of Burdwan, India
Objectives:
Forced expiratory volume in 1 (FEV1) second is known as the
amount of air volume that can forcibly be blown out in one second, after full
inspiration. Average FEV1 values between 80% and 120% are considered as
normal. The determinants of FEV1 are aimed to identify in the report for stage
III non-small cell lung cancer (SIIINSCLC) patients.
Background:
Previous research articles have reported that the average FEV1
values in healthy individuals depend on height, age, body mass index, sex and
ethnicity. Little studies have been performed regarding the FEV1 determinants
for SIIINSCLC patients.
Materials & Methods:
Published records on 239 SIIINSCLC patients with 23
study characters (variables/factors) are considered in the present study.
The study variable FEV1 is positive and heterogeneous. Statistical analysis
technique namely, joint generalized linear Log-normal models is used for
analyzing the response FEV1.
Results:
The mean FEV1 (MFEV1) is higher for SIIINSCLC patients who
are current smoker (P=0.0601), or who have lower body mass index (BMI)
(P=0.0599). Location of tumor is positively partially related (P=0.2365) with
the MFEV1. The MFEV1 is higher for SIIINSCLC patients with histology level at
squamous cell carcinoma (P=0.1088), or T-stage at level (T2=2) (P=0.1752),
or N-stage at level (N2=3) (P=0.1440) and (N4 or Nx=4) (P=0.0142) than the
other levels. The MFEV1 is higher for SIIINSCLC patients with chemotherapy
at levels (standard sequential=3) (P<0.0001) and (standard concurrent=4)
(P<0.0001), than the patientswith no chemo level. The FEV1 variance (FEV1V)
is higher for SIIINSCLC patients at older ages (P=0.1282), or never/ex-smoker
patients (P=0.2985). The FEV1V increases as the number of positive lymph
node stations increases (P=0.0017). The FEV1V is inversely related with
T-stage at level (T2=2) (P=0.0172) and at level (T4 or Tx=4) (P=0.0240). The
FEV1V decreases at the higher equivalent dose (P=0.1822), or at larger gross
tumor volume (P=0.0003), or at higher survival times (P=0.0451).
Conclusion:
The FEV1 determinants for both the mean and variance have
been identified for SIIINSCLC patients. These resultsmay help the lung cancer
specialists. The current findings of FEV1 (related to SIIINSCLC patients) are
new addition to the lung cancer literature.
Rabindra Nath Das is a Professor in the Depart-
ment of Statistics, The University of Burdwan,
Burdwan, West Bengal, India. He holds PhD in
statistics, from The University of Burdwan, In-
dia, and Post-Doc from Seoul National Univer-
sity, Seoul, Korea. He has authored about 85
research articles, and along with a research
monograph entitled- Robust Response Sur-
faces, Regression, and Positive Data Analyses,
published from CRC Press, Taylor and Francis,
Chapman and Hall. He wrote research articles
on design of experiments, Regression Analysis,
Demography, Quality Engineering, Civil Engi-
neering, Epidemiology, Medical sciences, En-
vironmental, Natural sciences etc. His special
area of interest is on Design of experiments,
Regression analysis, Quality Engineering and
Epidemiology. He has received ‘Gopal Kanji
Prize 2009’ by the Journal of Applied Statistics
and Routledge publications’ for the best article
published in the journal, entitled– A measure
of robust slope-rotatability for second-order
response surface experimental designs. He
has received certificate of appreciation for out-
standing research by the Editor-In-Chief, Journal
of Thyroid Science.
rabin.bwn@gmail.comBIOGRAPHY