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Virology Research Journal
|
Volume 2
Page 39
Note:
allied
academies
IMMUNOLOGY AND CELL BIOLOGY
BACTERIOLOGY AND INFECTIOUS DISEASES
&
Global Summit on
Global Congress on
J u n e 2 5 - 2 6 , 2 0 1 8 | A m s t e r d a m , N e t h e r l a n d s
Joint Event on
HUMAN C-CBL AND CBL-B PROTEINS
ARE MORE HIGHLY EXPRESSED IN THE
THYMUS COMPARED TO THE TESTIS
Mazo Kone, Rachida Salah
and
Harir Noria
University of Ibadan, Nigeria
Background & Objectives:
c-Cbl and Cbl-b are two members of the Cbl family
proteins, with a crucial role of down regulation of tyrosine kinase receptors.
They act as E3 ubiquitin ligases and are multivalent adaptor proteins,
making them important in maintaining homeostasis in the body. This study
investigated the expression level in thymus and testis in normal conditions.
Methods:
The expression level was assessed by immunochemistry of tissue
microarrays of normal thymus and testis biopsies.
Results:
Cbl-b and c-Cbl proteins were found to be highly expressed in
normal testis and thymus, indicated as yellowish brown granules in the
cyto-membrane and cytoplasm compared to controls. The c-Cbl appears to
be more highly expressed than the Cbl-b in the thymus, while c-Cbl appears
slightly stronger than Cbl-b in the testis. The thymus was found with a higher
grade compared to the testis.
Conclusion:
In this work we concluded, that in normal condition, thymus
tissue expresses more Cbl family proteins (c-Cbl and Cbl-b) than the testis
tissue in humans.
Mazo Kone has initiated to the world of research
during both his Bachelor and Master. Time
during which, he received basics training in Bi-
ology of Cancer, Physio-Pathology of Metabolic
diseases, Infectious diseases and many more.
However he quickly developed an interest for
the molecular biology of cancer, physiology of
the cell and infectious diseases. He has worked
on the oncogenic properties of human c-Cbl
and Cbl-b as master project work. Currently, he
is doing his PhD in Cell Biology and Genetics at
the University of Ibadan in Nigeria. His research
is on congenital infections in pregnancy both in
Mali and Nigeria. In general his research works
are axed on molecular biology of cancer and in-
fectious diseases. He is the Leader of Rachetes
Algeria since 2012, the promoter and the Man-
ager of the biomedical researcher project.
mzoalger@yahoo.frBIOGRAPHY
Mazo Kone et al., Virol Res J 2018, Volume 2