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Curr Trend Cardiol. 2017 | Volume 1 Issue 3
September 18-19, 2017 | Toronto, Canada
Annual Conference on
HEART DISEASES
Background:
Ganoderma lucidum
is a type of mushroom that
has been used for thousand years throughout Asia. It is known
to demonstrate numerous health benefiting properties
including antioxidant, antiinflammation, anticancer effects,
hypoglycaemic and blood cholesterol reducing properties.
This research was conducted to determine the efficacy
of
Ganoderma lucidum
polysaccharide peptides (PsP) as
antiinflammation, antioxidant, and endothelial protector in
cardiovascular disease.
Methods:
This is a true experimental study with pre- and
post-test design of 37 high risk patients of cardiovascular
disease based on the Framingham Risk Score that was
conducted for 3 months. They were advised to consume
PsP 3x250 mg as adjuvant to their previous medications.
They did some examines. Statistical analysis was conducted
using paired t-test for parametric data and Wilcoxon test for
nonparametric data.
Results:
From 37 patients we found that the administration
of PsP 3x250 mg could reduce total cholesterol level
from 219.46±49.49 to 201.43±81.63 (p=0.193). PsP
administration, however, decreased HDL cholesterol (HDL-C)
levels by 7.84±10.79 (p=0.000). The systolic blood pressure
decreased from130.14±43.37mmHg to 118.24±55.68mmHg
(p=0.109), and the diastolic blood pressure decreased from
80±25.74 mmHg to 73.24±33.85 mmHg (p=0.102). Despite a
great reduction of blood pressure to normal range, it was not
statistically significant. The reduction of anti-inflammatory
markers, interleukin 6 (IL-6), from 279.75±120.76 to
29.32±26.44 (p=0.000) and tumour necrosis factor alpha
(TNF alpha), from 13447.84 ± 2199.46 to 544.85 ± 292.06
(p=0.000) were significant.Malondialdehyde (MDA) level also
decreased significantly with PsP for 3 months (114.13±24.56
to 36.84±28.39, p=0.000). Circulating endothelial cell
(CEC) level significantly reduced (p=0.000) and endothelial
progenitor cell (EPC) level significantly increased (p=0.000).
Conclusions:
The administration of PsP
Ganoderma lucidum
for 3 months in high risk patients with hypertension can
reduce the blood pressure within normal range; improve
total cholesterol and LDL-C level and significantly pivotal role
as antiinflammation, antioxidant, and endothelial protector
in cardiovascular disease.
Speaker Biography
Djanggan Sargowo, MD, PhD, FIHA, FACC, FESC, FAPSC, FAsCC, FINASIM, is a Professor
at the University of Brawijaya, and is board certified in Internal Medicine and
Cardiovascular Disease. His clinical interests include management of ischemic heart
disease, congestive heart failure, hypertension, diabetes mellitus, dyslipidemia and
peripheral vascular disease. He received his MD from University of Gadjah Mada,
Yogyakarta, Indonesia. He received training in Internal Medicine at Airlangga University
and Cardiology at University of Indonesia. He received his PhD degree in Medicine from
University of Airlangga. In the past, Barry served as Head of Cardiology and Vascular
Department at Dr. Saiful Anwar General Hospital Malang and Director of Postgraduate
Program at University of Brawijaya. He is currently a Fellow of Indonesian Heart
Association, a Fellow of the American College of Cardiology, a Fellow of the European
Society of Cardiology, a Fellow of Asia Pacific Society of Cardiology, a Fellow of ASEAN
Federation of Cardiology, and a Fellow of Indonesian Society of Internal Medicine.
He serves as Director of Brawijaya University Teaching Hospital, Chairman of Malang
Molecular Biology Institute and as Chairman of Center for Degenerative Diseases,
Brawijaya University.
e:
djanggan@yahoo.comPolysaccharide peptides of
Ganoderma lucidum
effects as antioxidant, antiinflammation, and
endothelial protector in high risk patients of atherosclerosis
Djanggan Sargowo, Olivia Handayani, Nizamuddin Ubaidillah, Adriyawan Widya, Vittryaturida, Kartika Siwi, Mirza Failasufi, Fadhli Ramadhan, Hesti
Wulandari, Yoga Waranugraha and Dinarsari Hayuning Putri
University of Brawijaya, Indonesia