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Curr Trend Cardiol. 2017 | Volume 1 Issue 3
September 18-19, 2017 | Toronto, Canada
Annual Conference on
HEART DISEASES
Background:
Resveratrol and quercetine have useful effects
on cardiovascular system. resveratrol and quercetine were
shown to decline blood lipid. antidiabetic and antioxidant
effects of quercetine and resveratrol have been surveyed
alone. However, this experiment aimed at investigative
protective effects of this combination in rats with
acetaminophene-induced toxicity.
Methods:
The rats, weighting between 200-220 grams,
were randomly divided into 6 groups (n=7): 1-Control (only
receive chow diet), 2- acetaminophene at day of 0 and then
receive normal saline for 6 days (640 mg/kg bw, po), 3-
acetaminopheneat dayof 0and then receiveN-acetylcysteine
for 6 days(150 mg/kg bw, po), 4- acetaminophene at day of
0 and then receive Quercetine for 6 days (20 mg/kg bw, po),
5- acetaminophene at day of 0 and then receive Resveratrol
for 6 days (30 mg/kg bw, po), 6- acetaminophene at day of 0
and then receive Resveratrol (30 mg/kg bw, po) + quercetine
(20 mg/kg bw, po) for 6 days. After 7 days of treatment
heart were removed and their histology was examined by
pathologist. Antioxidant capacity of heart and plasma as well
as heart enzyme were determined.
Results:
MDA levels in the serum and heart were increased
in toxic group, whereas total antioxidant reduced. MDA
levels significantly reduced and total antioxidant increased
in Resveratrol and Quercetine compared with non-treated
group. These changes were more significant in combination
group (p<0.05). Creatine phosphokinase-MB, lactate
dehydrogenase and aspartate aminotransferase significantly
increased in toxic group. These enzyme significantly reduced
by Resveratrol and Quercetine. These reduction were more
significant in combination group (p<0.05). The structure
change of heart in hematoxylin and eosin staining was not
significant, while trichrome staining showed that heart
changes normalized in Resveratrol and Quercetine groups.
These reductions were more significant in combination
group.
Conclusion:
treatment of rats with Resveratrol and
Quercetine improved cardiac changes by an additive effect.
The useful effects of this combination on heart function were
associated with normalize of MDA, total antioxidant, heart
enzymes and an improved structure change.
e:
fmirzaei90@yahoo.comProtective effect of resveratrol and quercetine on heart against acetaminophene-induced toxicity in
male rat
Fatemeh Mirzaei
1
and
Ebrahim Abbasi Oshaghi
2
1
Kermanshah University of Medical sciences, Iran
2
Hamadan University of Medical Sciences Hamadan, Iran