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Journal of Public Health Policy and Planning | Volume 3
April 08-09, 2019 | Zurich, Switzerland
Health Care and Neuroscience
International Conference on
Notes:
A race against time: Reviewof Pediatric status Epilepticus diagnosis andmanagement
Ersida Buraniqi
Mayo Clinic, USA
Objective:
To identify factors associated with
in-hospital mortality in neonates and children
undergoing continuous electroencephalography
(cEEG) monitoring in the intensive care unit (ICU).
Methods:
We performed a retrospective
observational study in patients from birth to 21
years of age who underwent clinically indicated
cEEG in the ICU from 2011 to 2013. The main
outcome measure was in-hospital mortality.
Results:
Six-hundred and twenty-five patients
(54.2% male) met eligibility criteria, of whom
211 were neonates (55% male, 24.8% premature)
and 414 were pediatric patients (53.9% male).
Electrographic seizures occurred in 176 patients
(28.2%) and status epilepticus (SE) occurred
in 20 (11.4%). The time from ICU admission to
cEEG initiation was 16.7 (5.1-94.4) h. Eighty-nine
patients (14.2%) (30 [14.2%] neonates, and 59
[14.3%] pediatric patients) died in the hospital.
In neonates-after controlling for gender and
prematurity-independent factors associated with
mortality were prematurity (odds ratio [OR] 2.63.
95% confidence interval [CI] 1.06-6.5, p = 0.037),
presence of status epilepticus (SE); OR 8.82, 95%
CI 1.74-44.57, p = 0.008), and time from ICU
admission to initiation of cEEG (OR 1.002, 95%
CI 1.001-1.004 per hour, p = 0.008]. In pediatric
patients-after controlling for gender and age-
independent factors associated with mortality
were the absence of seizures factors associated
with mortality were absence of seizures (OR = 4.3,
(95% CI: 1.5-12.4), p = 0.007), the presence of SE
(OR 7.76, 95% CI 1.47-40.91, p = 0.016), and the
time from ICU admission to initiation of cEEG (OR
1.001, 95% CI 1.0002-1.001, per hour, p = 0.005].
Significance:
Both presence of electrographic SE
and time from ICU admission to cEEG initiation
were independent factors associated with
mortality in neonates and pediatric patients with
cEEG in the ICU.
Speaker Biography
Ersida Buraniqi has completed her MD at the Istanbul Faculty of
Medicine, in Turkey, and her postdoctoral studies in Epilepsy and
Clinical Neurophysiology at Boston Children’s Hospital and Harvard
Medical School in Boston, USA. She is now a Child Neurology Resident
at the Mayo Clinic in Minnesota, USA. She has presented her scientific
work in more than 20 national and international conferences and
meetings, and has been serving as an editorial board member of
scientific journals.
e:
ersidaunivers@gmail.com