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Journal of Public Health Policy and Planning | Volume 3

April 08-09, 2019 | Zurich, Switzerland

Health Care and Neuroscience

International Conference on

Alpha-lipoic acid mitigates toxic-induced demyelination in the Corpus Callosum by

lessening of oxidative stress and stimulation of Polydendrocytes proliferation

Mehdi Mehdizadeh

Iran University of Medical Sciences, Iran

ultiple Sclerosis (MS), is a disease that

degenerates myelin in central nervous

system (CNS). Reactive oxygen species (ROSs) are

toxic metabolites, and accumulating data indicate

that ROSs-mediated apoptosis of oligodendrocytes

(OLGs) plays amajor role in the pathogenesis of MS

under oxidative stress conditions. In this study, we

investigated the role of endogenous antioxidant

alpha-lipoic acid (ALA) as ROSs scavenger in

the OLGs loss and myelin degeneration during

cuprizone (cup)-induced demyelination in the

experimental model of MS. Our results have

shown that ALA treatment significantly increased

population of mature OLGs (MOG+ cells), as well as

decreased oxidative stress (ROSs, COX-2 and PGE2)

and apoptosis mediators (caspase-3 and Bax/

Bcl2 ratio) in corpus callosum (CC). Surprisingly,

ALA significantly stimulates population of NG2

chondroitin sulfate proteoglycan positive glia

(NG2+ cells or polydendrocytes), from week

4 afterward. Accordingly ALA could prevent

apoptosis, delays demyelination and recruits

OLGs survival and regeneration mechanisms in

CC. We conclude that ALA has protective effects

against toxic demyelination via reduction of redox

signaling, and alleviation of polydendrocytes

vulnerability to excitotoxic challenge.

Speaker Biography

Professor Mehdi Mehdizadeh has a PhD in Anatomical Sciences from

Tehran University of Medical Sciences. He is a member of Cellular

and Molecular Research Center, Faculty of Advanced Technologies in

Medicine, Department of Anatomical Sciences, IUMS, Tehran, Iran.

Professor Mehdizadeh worked as a Fellow at the German Research

Center for Biotechnology on Transgenic Animals. He is author and

co-author of over 100 peer-reviewed scientific articles, and has

contributed numerous book chapters.