health-neuroscience-2019-keynote

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April 08-09, 2019 | Zurich, Switzerland
Health Care and Neuroscience
International Conference on
Page 15
Journal of Public Health Policy and Planning | Volume 3
Notes:
Anti-inflammatoryeffectofseveralphytochemicals
suchas curcumin, resveratrol, polyunsaturated
fatty acids (PUFAs) and ginsenosides has been
extensively studied. However, their underlying
mechanismagainstneuroinflammatorypathogenesis
of neurodegenerative diseases is still unclear,
especially in connection between their dietary
supplementation and reversal of brain neuronal
damage or dysfunction. In this article, we analyze
anti-oxidative and anti-inflammatory effects of
phytochemicals,andthendiscusstheircommunication
approaches with brain microenvironment and the
potential binding receptors onmicroglia, astrocytes
andneurons. Thesedata showthat phytochemicals
may modulate and suppress neuroinflammation
by several approaches: 1) amelioration of systemic
inflammation and inflammatory infiltration via
blood brain barrier (BBB); 2) direct permeation into
brain parenchyma and binding to aryl hydrocarbon
receptor (AHR), leading toneuroprotectiveeffect; 3)
enhancedintegrityofdisruptedBBB;and4)improved
gastrointestinal function, signaling to the brain by
vagal/inflammatory reflex, to promote glial and
neuronal activities. Therefore, thesephytochemicals
have a potential neuroprotective implication, and
development of strategies for preventing these
diseases represents a considerable public health
concern and socioeconomic burden.
Speaker Biography
Jintang Wang is Associate Professor of Neuroimmunology at Beijing
Geriatric Hospital and a recipient of fellowship award from Johns
Hopkins University School of Medicine, sponsored by Milstein Medical
Asian American Partnership (MMAAP) Foundation. His research is
focused on neuroinflammatory mechanism underlying pathogenesis
of neurodegenerative diseases and anti-inflammatory mechanism of
phytochemicals. Research projects use α-synuclein and cytokines or
phytochemicals to stimulate glial cells and address their interaction
mechanism by determining activation of canonical inflammatory
pathway. He has published more than 20 papers in reputed journals
and is a review expert of Neural Regeneration Research journal.
e:
Jintang Wang
Yuetao Song1, Zheng Chen1 and Sean X Leng2
1Beijing Geriatric Hospital, China
2Johns Hopkins University School of Medicine, USA
Connection between Gut-derived Phytochemical molecules and Brain
Inflammatory Cascade